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    C20h6orf89 similar to human chromosome 6 open reading frame 89 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294311, updated on 27-Dec-2024

    Summary

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    Official Symbol
    C20h6orf89provided by RGD
    Official Full Name
    similar to human chromosome 6 open reading frame 89provided by RGD
    Primary source
    RGD:735065
    See related
    EnsemblRapid:ENSRNOG00000000524 AllianceGenome:RGD:735065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD735065
    Summary
    Predicted to be involved in several processes, including chromatin remodeling; epithelial cell proliferation; and wound healing. Predicted to act upstream of or within several processes, including collagen metabolic process; connective tissue replacement; and response to bleomycin. Predicted to be located in several cellular components, including midbody; nucleolus; and plasma membrane. Predicted to be active in Golgi membrane. Orthologous to human C6orf89 (chromosome 6 open reading frame 89). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 163.6), Heart (RPKM 111.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C20h6orf89 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (7324105..7368482)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (7322483..7362054)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6869870..6910022)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547155 Neighboring gene peptidylprolyl isomerase like 1 Neighboring gene transfer RNA threonine (anticodon AGU) 18 Neighboring gene uncharacterized LOC120098949 Neighboring gene peptidase inhibitor 16 Neighboring gene uncharacterized LOC134483863 Neighboring gene mitochondrial carrier 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells. Liu HJ, et al. PLoS One, 2011. PMID 21857995, Free PMC Article
    2. C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the golgi and the midbody. Lalioti VS, et al. J Cell Physiol, 2013 Sep. PMID 23460338
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72991

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within collagen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within response to bleomycin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bombesin receptor-activated protein C6orf89 homolog
    Names
    uncharacterized protein C6orf89 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199379.3 → NP_955411.1  bombesin receptor-activated protein C6orf89 homolog

      See identical proteins and their annotated locations for NP_955411.1

      Status: VALIDATED

      Source sequence(s)
      BC062242, JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q6P6G2
      UniProtKB/TrEMBL
      A0A1W2Q646, A6JJU4
      Related
      ENSRNOP00000084100.1, ENSRNOT00000102727.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      7324105..7368482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098522.2 → XP_038954450.1  bombesin receptor-activated protein C6orf89 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1A0

    2. XM_039098520.2 → XP_038954448.1  bombesin receptor-activated protein C6orf89 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1A0

    3. XM_039098528.2 → XP_038954456.1  bombesin receptor-activated protein C6orf89 homolog isoform X6

      UniProtKB/TrEMBL
      A0A0G2JVJ4, A0A8I5ZPM7
      Related
      ENSRNOP00000000631.4, ENSRNOT00000000631.6

    4. XM_063279034.1 → XP_063135104.1  bombesin receptor-activated protein C6orf89 homolog isoform X8

    5. XM_063279036.1 → XP_063135106.1  bombesin receptor-activated protein C6orf89 homolog isoform X10

    6. XM_006256182.5 → XP_006256244.1  bombesin receptor-activated protein C6orf89 homolog isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q6A8, A0A8I5ZPM7
      Related
      ENSRNOP00000076127.3, ENSRNOT00000093638.3

    7. XM_039098529.2 → XP_038954457.1  bombesin receptor-activated protein C6orf89 homolog isoform X7

    8. XM_063279035.1 → XP_063135105.1  bombesin receptor-activated protein C6orf89 homolog isoform X9

    9. XM_006256172.5 → XP_006256234.1  bombesin receptor-activated protein C6orf89 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1A0

    10. XM_063279032.1 → XP_063135102.1  bombesin receptor-activated protein C6orf89 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1A0

    11. XM_063279031.1 → XP_063135101.1  bombesin receptor-activated protein C6orf89 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1A0

    12. XM_063279033.1 → XP_063135103.1  bombesin receptor-activated protein C6orf89 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1A0
      Related
      ENSRNOP00000076205.3, ENSRNOT00000093736.3

    13. XM_006256181.5 → XP_006256243.1  bombesin receptor-activated protein C6orf89 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1A0

    14. XM_039098524.2 → XP_038954452.1  bombesin receptor-activated protein C6orf89 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1A0

    RNA

    1. XR_010060642.1 RNA Sequence

    2. XR_010060641.1 RNA Sequence

    3. XR_010060643.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6G2.1 GenPept UniProtKB/Swiss-Prot:Q6P6G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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