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    Slc25a10 solute carrier family 25 member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170943, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc25a10provided by RGD
    Official Full Name
    solute carrier family 25 member 10provided by RGD
    Primary source
    RGD:621430
    See related
    EnsemblRapid:ENSRNOG00000036693 AllianceGenome:RGD:621430
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dic
    Summary
    Enables malate transmembrane transporter activity and phosphate transmembrane transporter activity. Involved in malate transport and phosphate ion transport. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 611.4), Adrenal (RPKM 249.3) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Slc25a10 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106264396..106271895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105765598..105775159)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109665682..109674782)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized LOC103693493 Neighboring gene glucagon receptor Neighboring gene MAPK regulated co-repressor interacting protein 1 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC93224

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in dicarboxylic acid transport  
    involved_in glyceraldehyde-3-phosphate biosynthetic process  
    involved_in lipid transport  
    involved_in malate transmembrane transport  
    involved_in malate transport PubMed 
    involved_in oxaloacetate transport  
    involved_in oxaloacetate(2-) transmembrane transport  
    involved_in phosphate ion transmembrane transport  
    involved_in phosphate ion transport PubMed 
    involved_in succinate transmembrane transport  
    involved_in sulfate transmembrane transport  
    involved_in thiosulfate transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    mitochondrial dicarboxylate carrier
    Names
    dicarboxylate transporter), member 10
    solute carrier family 25 (mitochondrial carrier
    solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133418.2NP_596909.1  mitochondrial dicarboxylate carrier

      See identical proteins and their annotated locations for NP_596909.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O89035
      Related
      ENSRNOP00000078001.2, ENSRNOT00000106118.2
      Conserved Domains (1) summary
      pfam00153
      Location:94189
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106264396..106271895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596977.3XP_017452466.1  mitochondrial dicarboxylate carrier isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y824
      Related
      ENSRNOP00000051846.2, ENSRNOT00000054963.4
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