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    Ntrk3 neurotrophic receptor tyrosine kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29613, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ntrk3provided by RGD
    Official Full Name
    neurotrophic receptor tyrosine kinase 3provided by RGD
    Primary source
    RGD:3214
    See related
    EnsemblRapid:ENSRNOG00000018674 AllianceGenome:RGD:3214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    trkC
    Summary
    Enables GPI-linked ephrin receptor activity. Involved in several processes, including negative regulation of astrocyte differentiation; nervous system development; and response to corticosterone. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of borna disease. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 154.8), Adrenal (RPKM 34.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Ntrk3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (141526192..141913575, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (132116472..132503849, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (139890537..140262503, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099860 Neighboring gene uncharacterized LOC102553862 Neighboring gene uncharacterized LOC120099861 Neighboring gene uncharacterized LOC134485141 Neighboring gene uncharacterized LOC103691168 Neighboring gene mitochondrial ribosomal protein L46

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity PubMed 
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables neurotrophin binding  
    enables neurotrophin receptor activity  
    enables neurotrophin receptor activity  
    enables neurotrophin receptor activity  
    enables p53 binding  
    enables p53 binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein serine/threonine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 29
    Items 1 - 25 of 65
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in activation of GTPase activity  
    acts_upstream_of activation of protein kinase B activity  
    acts_upstream_of axon extension involved in regeneration  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell differentiation  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to retinoic acid PubMed 
    involved_in chromatin remodeling  
    involved_in circadian rhythm  
    involved_in cochlea development PubMed 
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in heart development  
    involved_in heart development  
    involved_in heart development  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    acts_upstream_of_or_within lens fiber cell differentiation  
    involved_in macrophage colony-stimulating factor signaling pathway  
    acts_upstream_of_or_within mechanoreceptor differentiation  
    involved_in multicellular organism development  
    acts_upstream_of_or_within myelination in peripheral nervous system  
    involved_in negative regulation of astrocyte differentiation PubMed 
    involved_in negative regulation of protein phosphorylation  
    involved_in nervous system development  
    involved_in neuron fate specification PubMed 
    involved_in neuron migration PubMed 
    acts_upstream_of_or_within neuronal action potential propagation  
    involved_in neurotrophin signaling pathway  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    acts_upstream_of positive regulation of MAP kinase activity  
    acts_upstream_of_or_within positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of axon extension involved in regeneration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of positive chemotaxis  
    involved_in positive regulation of positive chemotaxis  
    acts_upstream_of_or_within positive regulation of synapse assembly  
    involved_in postsynaptic density assembly PubMed 
    involved_in postsynaptic density assembly PubMed 
    involved_in regulation of neural precursor cell proliferation PubMed 
    involved_in regulation of presynapse assembly PubMed 
    involved_in regulation of presynapse assembly PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to corticosterone PubMed 
    involved_in response to ethanol PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 65
    Component Evidence Code Pubs
    located_in Golgi membrane  
    is_active_in axon  
    located_in cytoplasm  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane PubMed 
    part_of receptor complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    NT-3 growth factor receptor
    Names
    GP145-TrkC
    neural receptor protein-tyrosine kinase (trkC)
    neurotrophic tyrosine kinase, receptor, type 3
    trk-C
    trkC tyrosine kinase
    NP_001257584.1
    NP_001257585.1
    NP_062121.1
    XP_008757735.1
    XP_038965559.1
    XP_038965566.1
    XP_063143774.1
    XP_063143787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270655.1NP_001257584.1  NT-3 growth factor receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001257584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      L03813, L14446
      UniProtKB/TrEMBL
      A0A8L2ULV7
      Related
      ENSRNOP00000049463.2, ENSRNOT00000045165.5
      Conserved Domains (7) summary
      cd05094
      Location:532832
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    2. NM_001270656.1NP_001257585.1  NT-3 growth factor receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001257585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcritp and encodes the longest isoform (1).
      Source sequence(s)
      L03813, L14447
      UniProtKB/Swiss-Prot
      Q03351
      UniProtKB/TrEMBL
      A0A8L2ULV7
      Related
      ENSRNOP00000044402.5, ENSRNOT00000046849.7
      Conserved Domains (8) summary
      cd05094
      Location:532857
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    3. NM_019248.2NP_062121.1  NT-3 growth factor receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_062121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      L03813, L14445
      UniProtKB/TrEMBL
      A0A8L2ULV7
      Related
      ENSRNOP00000046059.2, ENSRNOT00000041839.5
      Conserved Domains (7) summary
      cd05094
      Location:532818
      PTKc_TrkC; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      141526192..141913575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287704.1XP_063143774.1  NT-3 growth factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8L2ULV7
    2. XM_039109638.2XP_038965566.1  NT-3 growth factor receptor isoform X4

      UniProtKB/TrEMBL
      A0A8I6ALQ4
      Conserved Domains (8) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
      cl21453
      Location:532572
      PKc_like; Protein Kinases, catalytic domain
    3. XM_039109631.2XP_038965559.1  NT-3 growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALQ4
      Conserved Domains (8) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
      cl21453
      Location:532572
      PKc_like; Protein Kinases, catalytic domain
    4. XM_008759513.4XP_008757735.1  NT-3 growth factor receptor isoform X3

      See identical proteins and their annotated locations for XP_008757735.1

      UniProtKB/TrEMBL
      A0A8I6ALQ4, Q68G04
      Related
      ENSRNOP00000094926.2, ENSRNOT00000110436.2
      Conserved Domains (7) summary
      sd00031
      Location:105128
      LRR_1; leucine-rich repeat [structural motif]
      pfam00047
      Location:214299
      ig; Immunoglobulin domain
      pfam01462
      Location:3151
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:103160
      LRR_8; Leucine rich repeat
      pfam16920
      Location:163208
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cd00096
      Location:218221
      Ig; Ig strand A' [structural motif]
      cd04971
      Location:304396
      IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains
    5. XM_063287717.1XP_063143787.1  NT-3 growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8I6ALQ4, Q68G04
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