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    Gps1 G protein pathway suppressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117039, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gps1provided by RGD
    Official Full Name
    G protein pathway suppressor 1provided by RGD
    Primary source
    RGD:621532
    See related
    EnsemblRapid:ENSRNOG00000046698 AllianceGenome:RGD:621532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MFH
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 389.1), Testes (RPKM 304.0) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gps1 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106548646..106553729)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106050323..106055407)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109966875..109971912)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene carbonyl reductase 2 like 1 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1-like Neighboring gene uncharacterized LOC120095225

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein deneddylation  
    involved_in protein deneddylation  
    Component Evidence Code Pubs
    part_of COP9 signalosome  
    part_of COP9 signalosome  
    part_of COP9 signalosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    GPS-1
    JAB1-containing signalosome subunit 1
    SGN1
    signalosome subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270939.1NP_001257868.1  COP9 signalosome complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_001257868.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, com pared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC061746, CB792560, X87885
      UniProtKB/Swiss-Prot
      P97834
      Related
      ENSRNOP00000103317.1, ENSRNOT00000160627.1
      Conserved Domains (2) summary
      pfam01399
      Location:320424
      PCI; PCI domain
      pfam10602
      Location:123305
      RPN7; 26S proteasome subunit RPN7
    2. NM_053969.3NP_446421.3  COP9 signalosome complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_446421.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC061746, CB771566
      UniProtKB/Swiss-Prot
      P97834
      UniProtKB/TrEMBL
      A0A0G2JT06
      Related
      ENSRNOP00000066704.3, ENSRNOT00000071645.4
      Conserved Domains (2) summary
      pfam01399
      Location:359463
      PCI; PCI domain
      pfam10602
      Location:162344
      RPN7; 26S proteasome subunit RPN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106548646..106553729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268313.1XP_063124383.1  COP9 signalosome complex subunit 1 isoform X6

      UniProtKB/Swiss-Prot
      P97834
      UniProtKB/TrEMBL
      A6HLJ7
      Related
      ENSRNOP00000111333.1, ENSRNOT00000174039.1
    2. XM_063268312.1XP_063124382.1  COP9 signalosome complex subunit 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JW80, A6HLJ8
      Related
      ENSRNOP00000069778.2, ENSRNOT00000085821.3
    3. XM_063268314.1XP_063124384.1  COP9 signalosome complex subunit 1 isoform X7

      UniProtKB/Swiss-Prot
      P97834
    4. XM_063268308.1XP_063124378.1  COP9 signalosome complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW80, A6HLJ8
    5. XM_063268309.1XP_063124379.1  COP9 signalosome complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW80, A6HLJ8
    6. XM_063268311.1XP_063124381.1  COP9 signalosome complex subunit 1 isoform X4

      UniProtKB/Swiss-Prot
      P97834
    7. XM_063268310.1XP_063124380.1  COP9 signalosome complex subunit 1 isoform X3

      UniProtKB/Swiss-Prot
      P97834
      UniProtKB/TrEMBL
      A6HLJ9
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