Itgb5 integrin subunit beta 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgb5provided by RGD
Official Full Name: integrin subunit beta 5provided by RGD
Primary source: RGD:628869
See related: EnsemblRapid:ENSRNOG00000001795 AllianceGenome:RGD:628869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563276
Summary: Enables signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; endodermal cell differentiation; and stress fiber assembly. Predicted to be located in cell leading edge. Predicted to be part of integrin alphav-beta5 complex. Predicted to be active in several cellular components, including focal adhesion; glutamatergic synapse; and synaptic membrane. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 351.5), Heart (RPKM 229.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (80333588..80449373, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (66828428..66944231, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (70056500..70172164, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.
Title: CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.
Integrin alphavbeta5 which induces LSECs dysfunction, promoting hepatic sinusoidal capillarization regulates VN expression via ERK/FAK pathway under high glucose/ox-LDL
Title: High glucose/ox-LDL induced hepatic sinusoidal capillarization via αvβ5/FAK/ERK signaling pathway.
the effects on cardiac fibroblasts , isolated by spontaneously hypertensive rats (SHR), of integrin alphanubeta5 inhibition in myofibroblast differentiation.
Title: Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats.
The possible functional roles of integrin alphavbeta5 in endothelial cells of the splenic sinus are discussed.
Title: Integrin αvβ5 in endothelial cells of rat splenic sinus: an immunohistochemical and ultrastructural study.
Authors conclude that MerTK activation via FAK and F-actin recruitment via Rac1 both require MFG-E8-ligated alphavbeta5 integrin. Both pathways are independently activated and required for clearance phagocytosis.
Title: Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.
Thy-1-integrin alpha(v)beta(5) interactions inhibit contraction-induced latent TGF-beta1 activation, presumably by blocking the binding of extracellular matrix-bound latent TGF-beta1 with integrin alpha(v)beta(5).
Title: Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.
Data suggest that CD81 does not function as a binding receptor by itself but promotes photoreceptor outer segment particle binding through functional interaction specifically with alpha v beta5 integrin.
Title: Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.

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General gene information

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Markers

AA475909 (e-PCR), detects polymorphism
- UniSTS:143009

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta5 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-5

Names: integrin, beta 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147139.2 → NP_671480.2 integrin beta-5 precursor

Status: VALIDATED

Source sequence(s)

AA859274, CA506053, CB731093, CO405730, CO567685, DV216421, DY316865, EV769502, EV772196, EX490541

UniProtKB/TrEMBL

A0A8I5ZKE8, A0A8I6AQL1

Related

ENSRNOP00000077937.1, ENSRNOT00000076955.4

Conserved Domains (5) summary

smart00187
Location:35 → 463

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:635 → 718

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:743 → 781

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:465 → 493

I-EGF_1; Integrin beta epidermal growth factor like domain 1

NF033759
Location:479 → 644

exchanger_TraA; outer membrane exchange protein TraA