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    Mfsd4a major facilitator superfamily domain containing 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498228, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mfsd4aprovided by RGD
    Official Full Name
    major facilitator superfamily domain containing 4Aprovided by RGD
    Primary source
    RGD:1566090
    See related
    EnsemblRapid:ENSRNOG00000024657 AllianceGenome:RGD:1566090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mfsd4; RGD1566090
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in hexose transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD4A (major facilitator superfamily domain containing 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 103.8), Thymus (RPKM 77.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd4a in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46015321..46062633, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43469488..43510467, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48807720..48848997, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 45, member 3 Neighboring gene uncharacterized LOC134481494 Neighboring gene ETS transcription factor ELK4 Neighboring gene uncharacterized LOC134481495 Neighboring gene cyclin-dependent kinase 18 Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, et al. PeerJ, 2019. PMID 31687280, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in hexose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 4A
    Names
    major facilitator superfamily domain containing 4
    major facilitator superfamily domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109069.2 → NP_001102539.1  major facilitator superfamily domain-containing protein 4A isoform 1

      See identical proteins and their annotated locations for NP_001102539.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC39, D4A6P2
      Related
      ENSRNOP00000061845.1, ENSRNOT00000068003.4
      Conserved Domains (2) summary
      cd06174
      Location:18 → 480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:22 → 442
      MFS_1; Major Facilitator Superfamily

    2. NM_001429795.1 → NP_001416724.1  major facilitator superfamily domain-containing protein 4A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC39, D4A6P2

    3. NM_001429796.1 → NP_001416725.1  major facilitator superfamily domain-containing protein 4A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K6P5

    4. NM_001429797.1 → NP_001416726.1  major facilitator superfamily domain-containing protein 4A isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6GFK9

    5. NM_001429798.1 → NP_001416727.1  major facilitator superfamily domain-containing protein 4A isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IC40

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      46015321..46062633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272534.1 → XP_063128604.1  major facilitator superfamily domain-containing protein 4A isoform X4

    2. XM_006249791.3 → XP_006249853.1  major facilitator superfamily domain-containing protein 4A isoform X1

      Related
      ENSRNOP00000073892.2, ENSRNOT00000077857.3
      Conserved Domains (2) summary
      cd06174
      Location:18 → 480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:22 → 442
      MFS_1; Major Facilitator Superfamily

    3. XM_063272533.1 → XP_063128603.1  major facilitator superfamily domain-containing protein 4A isoform X3

    4. XM_039090963.2 → XP_038946891.1  major facilitator superfamily domain-containing protein 4A isoform X2

      Related
      ENSRNOP00000087008.1, ENSRNOT00000100615.2
      Conserved Domains (1) summary
      cl28910
      Location:18 → 428
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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