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    Spag16 sperm associated antigen 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501158, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Spag16provided by RGD
    Official Full Name
    sperm associated antigen 16provided by RGD
    Primary source
    RGD:1565062
    See related
    EnsemblRapid:ENSRNOG00000054475 EnsemblRapid:ENSRNOG00000075101 AllianceGenome:RGD:1565062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565062
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in axoneme assembly. Predicted to act upstream of or within cerebrospinal fluid circulation; mucociliary clearance; and sperm axoneme assembly. Predicted to be located in axoneme and sperm flagellum. Predicted to be active in axonemal central apparatus. Orthologous to human SPAG16 (sperm associated antigen 16). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 137.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spag16 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (78782596..79702265)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (71333005..72252772)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (77027626..77833476)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 2 Neighboring gene uncharacterized LOC134480292 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480385 Neighboring gene phosphoglycerate kinase 1-like Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 1 Neighboring gene tubulin, beta 4B class IVb, pseudogene 4 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene von Willebrand factor C domain containing 2 like Neighboring gene uncharacterized LOC120094698 Neighboring gene BRCA1 associated RING domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional deficiencies and a reduced response to calcium in the flagellum of mouse sperm lacking SPAG16L. Lesich KA, et al. Biol Reprod, 2010 Apr. PMID 20042536, Free PMC Article
    2. Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Zhang Z, et al. Biol Reprod, 2006 Apr. PMID 16382026
    3. Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2. Zhang Z, et al. Biol Reprod, 2008 Jul. PMID 18367677, Free PMC Article
    4. A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme. Zhang Z, et al. Biol Reprod, 2007 Nov. PMID 17699735
    5. A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16. Zhang Z, et al. Mol Cell Biol, 2002 Nov. PMID 12391165, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187457

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal central apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonemal central apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated antigen 16 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134728.1 → NP_001128200.1  sperm-associated antigen 16 protein isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      BC158602
      UniProtKB/TrEMBL
      B0BMX7
      Related
      ENSRNOP00000063278.5, ENSRNOT00000068450.5
      Conserved Domains (3) summary
      COG2319
      Location:20 → 309
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:23 → 309
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:34 → 71
      7WD40; WD40 repeat [structural motif]

    2. NM_001401616.1 → NP_001388545.1  sperm-associated antigen 16 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F1M3E0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      78782596..79702265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267621.1 → XP_063123691.1  sperm-associated antigen 16 protein isoform X1

    2. XM_039084101.2 → XP_038940029.1  sperm-associated antigen 16 protein isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:354 → 618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:365 → 402
      7WD40; WD40 repeat [structural motif]

    3. XM_039084103.2 → XP_038940031.1  sperm-associated antigen 16 protein isoform X4

      Conserved Domains (2) summary
      cd00200
      Location:358 → 578
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:365 → 402
      7WD40; WD40 repeat [structural motif]

    4. XM_039084102.2 → XP_038940030.1  sperm-associated antigen 16 protein isoform X3

      Conserved Domains (2) summary
      cd00200
      Location:358 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:402 → 438
      7WD40; WD40 repeat [structural motif]

    5. XM_039084104.2 → XP_038940032.1  sperm-associated antigen 16 protein isoform X5

      Conserved Domains (2) summary
      cd00200
      Location:358 → 519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:366 → 402
      7WD40; WD40 repeat [structural motif]

    6. XM_063267623.1 → XP_063123693.1  sperm-associated antigen 16 protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6AFW5

    7. XM_063267624.1 → XP_063123694.1  sperm-associated antigen 16 protein isoform X7

    RNA

    1. XR_005488954.2 RNA Sequence

    2. XR_005488955.2 RNA Sequence

      Related
      ENSRNOT00000089203.3

    3. XR_010054628.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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