Maged1 MAGE family member D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maged1provided by RGD
Official Full Name: MAGE family member D1provided by RGD
Primary source: RGD:70898
See related: EnsemblRapid:ENSRNOG00000006756 AllianceGenome:RGD:70898
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nrage
Summary: Predicted to enable identical protein binding activity and transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of epithelial cell proliferation; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of macromolecule metabolic process. Predicted to act upstream of or within negative regulation of protein localization to nucleus; positive regulation of apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human MAGED1 (MAGE family member D1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 567.8), Adrenal (RPKM 452.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (63416464..63423167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (59422715..59429381, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (63803194..63809715, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells.
Title: Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells.
[Mage-D1 binding to activated p75NTR positively regulates mineralization of rat ectomesenchymal stem cells in vitro].
Title: [Mage-D1 binding to activated p75NTR positively regulates mineralization of rat ectomesenchymal stem cells in vitro].
Praja1, through ubiquitination and degradation of NRAGE, inhibits neuronal differentiation.
Title: The ubiquitin ligase Praja1 reduces NRAGE expression and inhibits neuronal differentiation of PC12 cells.
effects on neuritogenesis are promoted through interactions of Dlxin-1 with the neurotrophin receptor TrkA
Title: Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells.
The results are consistent with an important role for NRAGE in p75(NTR) signaling, as all cells that expressed p75(NTR) also expressed NRAGE. The wider distribution of NRAGE expression suggests that NRAGE may also participate in other signaling processes.
Title: Co-expression of the P75 neurotrophin receptor and neurotrophin receptor-interacting melanoma antigen homolog in the mature rat brain.
identification of NRAGE as a p75NTR interactor capable of inducing caspase activation and cell death through a JNK-dependent mitochondrial apoptotic pathway
Title: NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546850

Maged1 (e-PCR), detects polymorphism
- UniSTS:546850

Maged1 (e-PCR), detects polymorphism
- UniSTS:142887

AA998497 (e-PCR)
- UniSTS:248620

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase activity	TAS Traceable Author Statement more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanoma-associated antigen D1

Names: MAGE-D1 antigen; SNERG-1; melanoma antigen, family D, 1; neurotrophin receptor-interacting MAGE homolog; sertoli cell necdin-related gene protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053409.2 → NP_445861.1 melanoma-associated antigen D1

See identical proteins and their annotated locations for NP_445861.1

Status: PROVISIONAL

Source sequence(s)

BC081756

UniProtKB/Swiss-Prot

Q66HP3, Q9ES73, Q9JHZ6, Q9QX92

UniProtKB/TrEMBL

A6IQ11

Related

ENSRNOP00000009870.3, ENSRNOT00000009870.8

Conserved Domains (1) summary

pfam01454
Location:475 → 635

MAGE; MAGE family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

63416464..63423167 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280341.1 → XP_063136411.1 melanoma-associated antigen D1 isoform X1
XM_039100114.2 → XP_038956042.1 melanoma-associated antigen D1 isoform X2

Conserved Domains (3) summary

PHA03247
Location:10 → 432

PHA03247; large tegument protein UL36; Provisional

PRK12323
Location:228 → 432

PRK12323; DNA polymerase III subunit gamma/tau

pfam01454
Location:445 → 605

MAGE; MAGE family