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    Cnbd2 cyclic nucleotide binding domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296311, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cnbd2provided by RGD
    Official Full Name
    cyclic nucleotide binding domain containing 2provided by RGD
    Primary source
    RGD:1311678
    See related
    EnsemblRapid:ENSRNOG00000019992 AllianceGenome:RGD:1311678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cnmpd1; LRRGT00127
    Summary
    Predicted to enable cAMP binding activity. Predicted to be involved in spermatogenesis. Predicted to be located in cytosol. Predicted to be part of ribonucleoprotein complex. Orthologous to human CNBD2 (cyclic nucleotide binding domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 185.8), Brain (RPKM 134.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnbd2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (165279157..165357582)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144819166..144884825)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (152382245..152448105)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39 Neighboring gene PHD finger protein 20 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene SCAN domain-containing 1 Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene ferritin light chain 1 pseudogene Neighboring gene erythrocyte membrane protein band 4.1-like 1 Neighboring gene AAR2 splicing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. Krähling AM, et al. PLoS Genet, 2013. PMID 24339785, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-binding domain-containing protein 2
    Names
    cyclic nucleotide (cNMP) binding domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304368.1 → NP_001291297.1  cyclic nucleotide-binding domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AJL9, A6KIA6
      Related
      ENSRNOP00000093432.2, ENSRNOT00000095390.2
      Conserved Domains (2) summary
      COG0664
      Location:253 → 348
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:250 → 349
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      165279157..165357582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283375.1 → XP_063139445.1  cyclic nucleotide-binding domain-containing protein 2 isoform X4

    2. XM_063283374.1 → XP_063139444.1  cyclic nucleotide-binding domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6KIA6

    3. XM_039104613.2 → XP_038960541.1  cyclic nucleotide-binding domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6KIA6

    4. XM_039104614.2 → XP_038960542.1  cyclic nucleotide-binding domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      cd00038
      Location:250 → 349
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    5. XM_008762320.4 → XP_008760542.2  cyclic nucleotide-binding domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6KIA6
      Related
      ENSRNOP00000112305.1, ENSRNOT00000147018.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177681.1: Suppressed sequence

      Description
      NM_001177681.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript or this protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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