Cdk2 cyclin dependent kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk2provided by RGD
Official Full Name: cyclin dependent kinase 2provided by RGD
Primary source: RGD:70486
See related: EnsemblRapid:ENSRNOG00000006469 AllianceGenome:RGD:70486
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including DNA synthesis involved in mitotic DNA replication; cellular response to insulin stimulus; and liver regeneration. Located in nucleus. Used to study membranoproliferative glomerulonephritis. Biomarker of interstitial cystitis. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 127.6), Spleen (RPKM 69.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1714392..1721964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (1129878..1137431, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (3124953..3132533, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR125/CDK2 axis in cochlear progenitor cell proliferation.
Title: miR‑125/CDK2 axis in cochlear progenitor cell proliferation.
Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero- and Homomorphic Sex Chromosomes.
Title: Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero- and Homomorphic Sex Chromosomes.
MiR-21-3p mediates metabolism and cell fate alterations of tubular epithelial cells (TECs) via manipulating AKT/CDK2-FOXO1 pathway, and that is crucial in the regulation of energy metabolism of TECs during Sepsis and associated acute kidney injury.
Title: MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway.
These data suggested that AS-IV exerted beneficial effects on AngII -induced abnormal growth in rat VSMCs through disturbing cell cycle, especially block G1/S transition by attenuating CDK2 activity, which may hinder the process of pathological vascular remodeling during atherosclerosis.
Title: Astragaloside IV inhibits Angiotensin II-stimulated proliferation of rat vascular smooth muscle cells via the regulation of CDK2 activity.
that p52SHC3 plays an important role in maintaining the mitotic quiescence of neurons, while p52SHC1 regulates the proliferation of neural stem cells
Title: Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of Neurons and Neural Stem Cells.
CDK4 is a critical downstream target of MEN1-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 is dispensable for tumorigenesis in these neuroendocrine cell types.
Title: MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.
The Irf-1 overexpression-induced proliferation of VSMCs, the up-regulation of cyclin E/CDK2 and the acceleration of cell cycle progression are associated with ROS/Erk1/2 signaling pathway under high glucose conditions.
Title: Interferon regulatory factor-1 together with reactive oxygen species promotes the acceleration of cell cycle progression by up-regulating the cyclin E and CDK2 genes during high glucose-induced proliferation of vascular smooth muscle cells.
Suggest that FAK acts as a central coordinator of integrin and growth factor-mediated S-phase entry by regulating Cdk2 in EGF-stimulated hepatocytes.
Title: FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes.
Overexpressed cyclin E/CDK2 molecules were stably associated with p107 and p130 in FGF-treated cells in the context of E2F repressive complexes.
Title: Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins.
phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2
Title: Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables histone kinase activity	IEA Inferred from Electronic Annotation more info
contributes_to histone kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA synthesis involved in mitotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in centriole replication	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in lens development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance in response to DNA damage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in X chromosome	IEA Inferred from Electronic Annotation more info
located_in X chromosome	ISO Inferred from Sequence Orthology more info
located_in Y chromosome	IEA Inferred from Electronic Annotation more info
located_in Y chromosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	ISO Inferred from Sequence Orthology more info
part_of cyclin A1-CDK2 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin A1-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin A2-CDK2 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin A2-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin E1-CDK2 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin E1-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin E2-CDK2 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin E2-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 2

Names: cell division protein kinase 2; cyclin dependent kinase 2-alpha

NP_955795.1

EC 2.7.11.22

XP_006240840.1

EC 2.7.11.22

XP_038935306.1

EC 2.7.11.22

XP_038935307.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199501.2 → NP_955795.1 cyclin-dependent kinase 2

See identical proteins and their annotated locations for NP_955795.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O09136, Q63699

UniProtKB/TrEMBL

F6PTK8, Q6P751

Related

ENSRNOP00000032191.3, ENSRNOT00000031963.5

Conserved Domains (1) summary

cd07860
Location:3 → 286

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1714392..1721964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240778.3 → XP_006240840.1 cyclin-dependent kinase 2 isoform X1

See identical proteins and their annotated locations for XP_006240840.1

UniProtKB/Swiss-Prot

O09136, Q63699

UniProtKB/TrEMBL

A0A8I6AHN8

Related

ENSRNOP00000094402.1, ENSRNOT00000101553.2

Conserved Domains (1) summary

cd07860
Location:3 → 334

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
XM_039079378.2 → XP_038935306.1 cyclin-dependent kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 244

PKc_like; Protein Kinases, catalytic domain
XM_039079379.2 → XP_038935307.1 cyclin-dependent kinase 2 isoform X3

Conserved Domains (1) summary

cl21453
Location:1 → 196

PKc_like; Protein Kinases, catalytic domain