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    Slc38a6 solute carrier family 38, member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299139, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Slc38a6provided by RGD
    Official Full Name
    solute carrier family 38, member 6provided by RGD
    Primary source
    RGD:1310330
    See related
    EnsemblRapid:ENSRNOG00000022622 AllianceGenome:RGD:1310330
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snat6
    Summary
    Predicted to enable L-glutamate transmembrane transporter activity and L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Predicted to be located in synapse. Predicted to be active in plasma membrane. Orthologous to human SLC38A6 (solute carrier family 38 member 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 35.0), Spleen (RPKM 34.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc38a6 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97723526..97814394)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91987652..92076416)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96171756..96241512)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene tRNA methyltransferase 5 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4 Neighboring gene uncharacterized LOC120103552 Neighboring gene uncharacterized LOC102550345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. Bagchi S, et al. PLoS One, 2014. PMID 24752331, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-glutamate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables active monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inorganic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables secondary active transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutral amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 38 member 6
    Names
    N-system amino acid transporter 1
    NAT-1
    Na(+)-coupled neutral amino acid transporter 6
    Na+-dependent neutral amino acid transporter
    amino acid transporter SLC38A6
    probable sodium-coupled neutral amino acid transporter 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013099.1 → NP_001013117.1  solute carrier family 38 member 6

      Status: PROVISIONAL

      Source sequence(s)
      AY266018
      UniProtKB/Swiss-Prot
      Q6WWW3
      UniProtKB/TrEMBL
      A6HC57, F1LRY2
      Related
      ENSRNOP00000035818.3, ENSRNOT00000029328.5
      Conserved Domains (2) summary
      COG0814
      Location:45 → 447
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:45 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      97723526..97814394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112001.2 → XP_038967929.1  solute carrier family 38 member 6 isoform X1

      UniProtKB/TrEMBL
      A6HC57, F1LRY2
      Conserved Domains (1) summary
      cl00456
      Location:45 → 430
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. XM_063261713.1 → XP_063117783.1  solute carrier family 38 member 6 isoform X4

    3. XM_063261716.1 → XP_063117786.1  solute carrier family 38 member 6 isoform X7

    4. XM_063261715.1 → XP_063117785.1  solute carrier family 38 member 6 isoform X6

    5. XM_039112006.2 → XP_038967934.1  solute carrier family 38 member 6 isoform X9

      Conserved Domains (1) summary
      cl00456
      Location:45 → 150
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    6. XM_006240209.3 → XP_006240271.1  solute carrier family 38 member 6 isoform X2

      UniProtKB/TrEMBL
      A6HC57, F1LRY2
      Conserved Domains (2) summary
      COG0814
      Location:2 → 392
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:2 → 397
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    7. XM_006240210.4 → XP_006240272.1  solute carrier family 38 member 6 isoform X2

      UniProtKB/TrEMBL
      A6HC57, F1LRY2
      Conserved Domains (2) summary
      COG0814
      Location:2 → 392
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:2 → 397
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_063261712.1 → XP_063117782.1  solute carrier family 38 member 6 isoform X3

    9. XM_063261714.1 → XP_063117784.1  solute carrier family 38 member 6 isoform X5

    10. XM_039112004.2 → XP_038967932.1  solute carrier family 38 member 6 isoform X8

      Conserved Domains (1) summary
      cl00456
      Location:45 → 245
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_005505476.2 RNA Sequence

    2. XR_005505475.2 RNA Sequence

    3. XR_010052064.1 RNA Sequence

    4. XR_010052065.1 RNA Sequence

    5. XR_010052067.1 RNA Sequence

    6. XR_005505480.2 RNA Sequence

    7. XR_010052066.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WWW3.1 GenPept UniProtKB/Swiss-Prot:Q6WWW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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