Omp olfactory marker protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ompprovided by RGD
Official Full Name: olfactory marker proteinprovided by RGD
Primary source: RGD:3231
See related: AllianceGenome:RGD:3231
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables peptide binding activity. Predicted to be involved in sensory perception of smell. Predicted to act upstream of or within neurogenesis. Located in several cellular components, including acrosomal vesicle; dendritic knob; and sperm midpiece. Orthologous to human OMP (olfactory marker protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161851499..161852049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152440278..152440828, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163097159..163097709, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.
Title: Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.
Dynamic properties of alpha 1, loop 1, and the omega loop (loop 3) of OMP indicate that these three regions of OMP are all dynamic in solution on multiple time scales
Title: Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements.
The olfactory marker protein expression of VRNs was induced not only by AOB neurons but also by neurons of other parts of the central nervous system (CNS).
Title: Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94591 (e-PCR)
- UniSTS:119839

Omp (e-PCR), detects polymorphism
- UniSTS:144083

D1Mgh19 (e-PCR)
- UniSTS:118493

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic knob	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: olfactory marker protein

Names: olfactory neuronal-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012616.1 → NP_036748.1 olfactory marker protein

See identical proteins and their annotated locations for NP_036748.1

Status: PROVISIONAL

Source sequence(s)

M26926

UniProtKB/Swiss-Prot

P08523

UniProtKB/TrEMBL

A6I6C8

Conserved Domains (1) summary

pfam06554
Location:12 → 161

Olfactory_mark; Olfactory marker protein