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    Ark2n arkadia (RNF111) N-terminal like PKA signaling regulator 2N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307249, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ark2nprovided by RGD
    Official Full Name
    arkadia (RNF111) N-terminal like PKA signaling regulator 2Nprovided by RGD
    Primary source
    RGD:1308601
    See related
    EnsemblRapid:ENSRNOG00000017215 AllianceGenome:RGD:1308601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308601
    Summary
    Predicted to enable transcription corepressor activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of viral life cycle and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in chromatin. Orthologous to human ARK2N (arkadia (RNF111) N-terminal like PKA signaling regulator 2N). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 240.3), Heart (RPKM 196.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ark2n in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73431104..73520759, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (71155956..71243655, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (74012965..74059618, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348739 Neighboring gene uncharacterized LOC102551968 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene ATP synthase F1 subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ARK2N
    Names
    arkadia N-terminal like PKA signaling regulator 2N
    uncharacterized protein C18orf25 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107374.2 → NP_001100844.1  protein ARK2N

      See identical proteins and their annotated locations for NP_001100844.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KMV4, D4A3X1
      Related
      ENSRNOP00000086540.2, ENSRNOT00000103893.2
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 238
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      73431104..73520759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277296.1 → XP_063133366.1  protein ARK2N isoform X2

      UniProtKB/TrEMBL
      A0A8I6GF24, A6KMV3

    2. XM_039096776.2 → XP_038952704.1  protein ARK2N isoform X1

      UniProtKB/TrEMBL
      A6KMV4, D4A3X1
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 238
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    3. XM_039096777.2 → XP_038952705.1  protein ARK2N isoform X2

      UniProtKB/TrEMBL
      A0A8I6GF24, A6KMV3
      Conserved Domains (1) summary
      pfam15303
      Location:67 → 238
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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