Sirt3 sirtuin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sirt3provided by RGD
Official Full Name: sirtuin 3provided by RGD
Primary source: RGD:1308374
See related: EnsemblRapid:ENSRNOG00000013828 AllianceGenome:RGD:1308374
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 142.2), Adrenal (RPKM 122.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205371703..205394145, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (195942066..195964472, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (213613502..213636061, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway.
Title: SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-β1/smad2/3 signalling pathway.
The study on the role of O-GlcNAcylation of SIRT3 in regulating mitochondrial oxidative stress during simulate myocardial ischemia-reperfusion.
Title: The study on the role of O-GlcNAcylation of SIRT3 in regulating mitochondrial oxidative stress during simulate myocardial ischemia-reperfusion.
SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury.
Title: SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury.
The SIRT3/GSK-3beta/GLUT4 axis might be involved in maternal hypoxia-induced skeletal muscle insulin resistance in old male rat offspring.
Title: The SIRT3/GSK-3β/GLUT4 axis might be involved in maternal hypoxia-induced skeletal muscle insulin resistance in old male rat offspring.
The Mechanism of SIRT3 Regulating SRV2-Mediated Mitochondrial Fission of Fibroblasts to Inhibit Myocardial Fibrosis after Acute Myocardial Infarction.
Title: The Mechanism of SIRT3 Regulating SRV2-Mediated Mitochondrial Fission of Fibroblasts to Inhibit Myocardial Fibrosis after Acute Myocardial Infarction.
SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy.
Title: SIRT3 alleviates painful diabetic neuropathy by mediating the FoxO3a-PINK1-Parkin signaling pathway to activate mitophagy.
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
Title: SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression.
UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury.
Title: UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury.
The role of SIRT3 in mediating the cognitive deficits and neuroinflammatory changes associated with a developmental animal model of schizophrenia.
Title: The role of SIRT3 in mediating the cognitive deficits and neuroinflammatory changes associated with a developmental animal model of schizophrenia.
HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND).
Title: HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND).

Submit: New GeneRIF Correction See all GeneRIFs (78)

General gene information

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Markers

Sirt3 (e-PCR), detects polymorphism
- UniSTS:531294

RH133909 (e-PCR)
- UniSTS:217192

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine delactylase activity	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine delactylase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of catalase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide dismutase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Names: SIRT3L mitochondrial

NP_001099783.1

EC 2.3.1.286

EC 3.5.1.-

XP_006230588.1

EC 2.3.1.286

EC 3.5.1.-

XP_038963774.1

EC 2.3.1.286

EC 3.5.1.-

XP_038963784.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142583.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142585.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142587.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142589.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142595.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142598.1

EC 2.3.1.286

EC 3.5.1.-

XP_063142599.1

EC 2.3.1.286

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106313.2 → NP_001099783.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial

See identical proteins and their annotated locations for NP_001099783.1

Status: PROVISIONAL

Source sequence(s)

BC167006

UniProtKB/TrEMBL

A0A8I6A7C4, B2RZ31

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205371703..205394145 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286525.1 → XP_063142595.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X5

UniProtKB/TrEMBL

A6HXL1
XM_063286529.1 → XP_063142599.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X5

UniProtKB/TrEMBL

A6HXL1
XM_063286528.1 → XP_063142598.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6A7C4, B2RZ31
XM_039107846.2 → XP_038963774.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6A7C4, B2RZ31

Conserved Domains (1) summary

cd01408
Location:1 → 231

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
XM_063286513.1 → XP_063142583.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5XWT5, C6ZII9

Related

ENSRNOP00000078101.1, ENSRNOT00000116448.2
XM_063286515.1 → XP_063142585.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X3

UniProtKB/TrEMBL

C6ZII9
XM_006230526.5 → XP_006230588.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

UniProtKB/TrEMBL

C6ZII9, F7EYD5

Related

ENSRNOP00000018861.7, ENSRNOT00000018861.8

Conserved Domains (1) summary

cd01408
Location:74 → 308

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
XM_039107856.2 → XP_038963784.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X5

UniProtKB/TrEMBL

A6HXL1

Conserved Domains (1) summary

cl00195
Location:1 → 177

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_063286517.1 → XP_063142587.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6A7C4, B2RZ31
XM_063286519.1 → XP_063142589.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6A7C4, B2RZ31