U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Higd1a HIG1 hypoxia inducible domain family, member 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140937, updated on 27-Dec-2024

    Summary

    Official Symbol
    Higd1aprovided by RGD
    Official Full Name
    HIG1 hypoxia inducible domain family, member 1Aprovided by RGD
    Primary source
    RGD:620215
    See related
    EnsemblRapid:ENSRNOG00000019428 AllianceGenome:RGD:620215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hig1
    Summary
    Predicted to be involved in mitochondrial respirasome assembly and negative regulation of apoptotic process. Predicted to act upstream of or within several processes, including cellular response to glucose starvation; cellular response to hypoxia; and negative regulation of release of cytochrome c from mitochondria. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion. Orthologous to human HIGD1A (HIG1 hypoxia inducible domain family member 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 353.7), Muscle (RPKM 232.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Higd1a in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130391658..130400888, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121514152..121523382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130482492..130491888, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 40 Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene atypical chemokine receptor 2 Neighboring gene cytochrome P450 family 8 subfamily B member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    HIG1 domain family member 1A, mitochondrial
    Names
    HIG1 domain family, member 1A
    hypoxia induced gene 1
    hypoxia-inducible gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080902.4NP_543178.2  HIG1 domain family member 1A, mitochondrial

      See identical proteins and their annotated locations for NP_543178.2

      Status: PROVISIONAL

      Source sequence(s)
      BC059118
      UniProtKB/Swiss-Prot
      Q6PCV5, Q8VH49
      UniProtKB/TrEMBL
      A6I463
      Related
      ENSRNOP00000061362.1, ENSRNOT00000064114.5
      Conserved Domains (1) summary
      pfam04588
      Location:2878
      HIG_1_N; Hypoxia induced protein conserved region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130391658..130400888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.