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    Slain1 SLAIN motif family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361087, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slain1provided by RGD
    Official Full Name
    SLAIN motif family, member 1provided by RGD
    Primary source
    RGD:1308626
    See related
    EnsemblRapid:ENSRNOG00000024125 AllianceGenome:RGD:1308626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308626
    Summary
    Predicted to be involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Predicted to colocalize with microtubule plus-end. Orthologous to human SLAIN1 (SLAIN motif family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 126.7), Thymus (RPKM 50.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slain1 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86897476..86957113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (80482818..80542461)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (87862832..87906472)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene sciellin Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene endothelin receptor type B Neighboring gene uncharacterized LOC102550182

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SLAIN motif-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014139.2 → NP_001014161.1  SLAIN motif-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001014161.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D4A5Y9, Q5HZW0
      Conserved Domains (1) summary
      pfam15301
      Location:1 → 306
      SLAIN; SLAIN motif-containing family

    2. NM_001393854.1 → NP_001380783.1  SLAIN motif-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZRS3
      Related
      ENSRNOP00000081350.1, ENSRNOT00000117967.2
      Conserved Domains (1) summary
      pfam15301
      Location:185 → 617
      SLAIN; SLAIN motif-containing family

    3. NM_001393855.1 → NP_001380784.1  SLAIN motif-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ABM8
      Related
      ENSRNOP00000090352.1, ENSRNOT00000096527.2
      Conserved Domains (1) summary
      pfam15301
      Location:185 → 567
      SLAIN; SLAIN motif-containing family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86897476..86957113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093535.2 → XP_038949463.1  SLAIN motif-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      D4A5Y9, Q5HZW0
      Conserved Domains (1) summary
      pfam15301
      Location:1 → 306
      SLAIN; SLAIN motif-containing family
    Nucleotide Protein Strain
    Heading Accession and Version

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