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Rhoa ras homolog family member A [ Rattus norvegicus (Norway rat) ]

Gene ID: 117273, updated on 27-Dec-2024

Summary

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Official Symbol: Rhoaprovided by RGD
Official Full Name: ras homolog family member Aprovided by RGD
Primary source: RGD:619921
See related: EnsemblRapid:ENSRNOG00000050519 AllianceGenome:RGD:619921
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Arha; Arha2
Summary: Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; positive regulation of actin filament polymerization; and regulation of neuron projection development. Acts upstream of or within Rho protein signal transduction; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Located in several cellular components, including axon; dendritic spine; and neuronal cell body. Used to study membranous glomerulonephritis. Biomarker of artery disease (multiple); asthma; fetal alcohol syndrome; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (ras homolog family member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 1085.0), Kidney (RPKM 887.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Rhoa in Genome Data Viewer

Location:: 8q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117870548..117904303)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108991926..109025746)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117082440..117116244)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells.
Title: siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells.
TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
Title: TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis development.
Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-beta-catenin signaling axis and static & dynamic dual roles.
Title: Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles.
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
Title: Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats.
Title: Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats.
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA.
Title: Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA.
Effects of RhoA on depression-like behavior in prenatally stressed offspring rats.
Title: Effects of RhoA on depression-like behavior in prenatally stressed offspring rats.
Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway.
Title: Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway.
Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
Title: Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK.
Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current.
Title: Small G-protein RhoA is a potential inhibitor of cardiac fast sodium current.

Submit: New GeneRIF Correction See all GeneRIFs (219)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:532286

Rhoa (e-PCR), detects polymorphism
- UniSTS:532286

D3S1330E (e-PCR)
- UniSTS:147343

WI-18922 (e-PCR)
- UniSTS:62388

Arha2 (e-PCR), detects polymorphism
- UniSTS:166613

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	NAS Non-traceable Author Statement more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables Rho GDP-dissociation inhibitor binding	IPI Inferred from Physical Interaction more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables myosin binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Roundabout signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Roundabout signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Roundabout signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in alpha-beta T cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in aortic valve formation	IEA Inferred from Electronic Annotation more info
involved_in aortic valve formation	ISO Inferred from Sequence Orthology more info
involved_in apical junction assembly	IEA Inferred from Electronic Annotation more info
involved_in apical junction assembly	ISO Inferred from Sequence Orthology more info
involved_in apical junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in apolipoprotein A-I-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in beta selection	ISO Inferred from Sequence Orthology more info
involved_in bone trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cell junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to progesterone stimulus	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cerebral cortex cell migration	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic cleavage	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube lumen extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial tube lumen extension	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of actin cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cleavage furrow formation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cleavage furrow formation	ISO Inferred from Sequence Orthology more info
involved_in mitotic cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intracellular steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in polar body extrusion after meiotic divisions	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin polymerization or depolymerization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by endothelin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spindle localization	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress-activated protein kinase signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical junction complex	IEA Inferred from Electronic Annotation more info
located_in apical junction complex	ISO Inferred from Sequence Orthology more info
located_in apical junction complex	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming protein RhoA

Names: plysia ras-related homolog A2; ras homolog gene family, member A

NP_476473.1

EC 3.6.5.2

XP_006243761.1

EC 3.6.5.2

XP_006243762.1

EC 3.6.5.2

XP_006243763.1

EC 3.6.5.2

XP_038936642.1

EC 3.6.5.2

XP_063120856.1

EC 3.6.5.2

XP_063120857.1

EC 3.6.5.2

XP_063120858.1

EC 3.6.5.2

XP_063120859.1

EC 3.6.5.2

XP_063120860.1

EC 3.6.5.2

XP_063120861.1

EC 3.6.5.2

XP_063120862.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057132.3 → NP_476473.1 transforming protein RhoA

See identical proteins and their annotated locations for NP_476473.1

Status: PROVISIONAL

Source sequence(s)

AY026068

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117870548..117904303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264790.1 → XP_063120860.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_063264789.1 → XP_063120859.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_006243700.3 → XP_006243762.1 transforming protein RhoA isoform X1

See identical proteins and their annotated locations for XP_006243762.1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
XM_063264786.1 → XP_063120856.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Related

ENSRNOP00000091658.1, ENSRNOT00000094929.2
XM_063264788.1 → XP_063120858.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_063264787.1 → XP_063120857.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_006243699.3 → XP_006243761.1 transforming protein RhoA isoform X1

See identical proteins and their annotated locations for XP_006243761.1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
XM_063264792.1 → XP_063120862.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_039080714.2 → XP_038936642.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
XM_063264791.1 → XP_063120861.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347
XM_006243701.2 → XP_006243763.1 transforming protein RhoA isoform X1

See identical proteins and their annotated locations for XP_006243763.1

UniProtKB/Swiss-Prot

P61589

UniProtKB/TrEMBL

A0A8I6AFP1, A6I347

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC