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    Myo1c myosin 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65261, updated on 4-Jan-2025

    Summary

    Official Symbol
    Myo1cprovided by RGD
    Official Full Name
    myosin 1Cprovided by RGD
    Primary source
    RGD:620443
    See related
    EnsemblRapid:ENSRNOG00000004072 AllianceGenome:RGD:620443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MMIb; Myr2; MMI-beta
    Summary
    Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 638.1), Heart (RPKM 586.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Myo1c in Genome Data Viewer
    Location:
    10q24
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60996642..61019022)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60498372..60520752)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63803311..63819614)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene glutathione peroxidase 4, pseudogene 2 Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin binding  
    enables actin filament binding  
    enables actin filament binding PubMed 
    enables calmodulin binding PubMed 
    enables cytoskeletal motor activity  
    enables microfilament motor activity  
    enables microfilament motor activity PubMed 
    enables microfilament motor activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables small GTPase binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in actin filament-based movement  
    involved_in cellular response to type II interferon  
    acts_upstream_of_or_within cellular response to type II interferon  
    involved_in endocytosis  
    involved_in positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cellular response to insulin stimulus  
    involved_in positive regulation of cellular response to insulin stimulus PubMed 
    acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus  
    involved_in positive regulation of protein targeting to membrane  
    acts_upstream_of_or_within positive regulation of protein targeting to membrane  
    involved_in positive regulation of transcription by RNA polymerase III  
    involved_in protein targeting to membrane  
    involved_in protein targeting to membrane  
    involved_in protein transport  
    involved_in regulation of bicellular tight junction assembly  
    involved_in regulation of bicellular tight junction assembly  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vesicle transport along actin filament  
    acts_upstream_of_or_within vesicle transport along actin filament  
    Items 1 - 20 of 36
    Component Evidence Code Pubs
    part_of B-WICH complex  
    is_active_in actin cytoskeleton  
    located_in basal plasma membrane  
    located_in basal plasma membrane  
    located_in brush border  
    located_in brush border  
    located_in cell cortex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle membrane  
    located_in cytoplasmic vesicle membrane  
    part_of filamentous actin  
    part_of filamentous actin  
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in membrane  
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in membrane raft  
    is_active_in microvillus  
    located_in microvillus  
    located_in microvillus  
    part_of myosin complex  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleus  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in ruffle membrane PubMed 
    located_in stereocilium  
    located_in stereocilium bundle PubMed 
    located_in stereocilium membrane  
    NOT located_in stress fiber  
    Items 1 - 20 of 36

    General protein information

    Preferred Names
    unconventional myosin-Ic
    Names
    myosin I beta
    myosin IC
    myosin IC-like
    myosin heavy chain myr 2
    myosin-Ic
    unconventional myosin Myr2 I heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414168.1NP_001401097.1  unconventional myosin-Ic isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5ZQN4, A0A8I6ASB9
      Related
      ENSRNOP00000097261.1, ENSRNOT00000101210.2
    2. NM_023092.3NP_075580.2  unconventional myosin-Ic isoform 2

      See identical proteins and their annotated locations for NP_075580.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q63355
      UniProtKB/TrEMBL
      A0A8I5ZQN4
      Related
      ENSRNOP00000028929.7, ENSRNOT00000036666.7
      Conserved Domains (4) summary
      smart00015
      Location:737757
      IQ; Calmodulin-binding motif
      smart00242
      Location:24709
      MYSc; Myosin. Large ATPases
      cd01378
      Location:43699
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8551022
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60996642..61019022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086809.1XP_038942737.1  unconventional myosin-Ic isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQN4
      Related
      ENSRNOP00000102184.1, ENSRNOT00000155184.1
      Conserved Domains (3) summary
      smart00015
      Location:721741
      IQ; Calmodulin-binding motif
      cd01378
      Location:27683
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:8391020
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
    2. XM_063269827.1XP_063125897.1  unconventional myosin-Ic isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQN4, A0A8I6AQB5
      Related
      ENSRNOP00000096158.1, ENSRNOT00000117022.2
    3. XM_039086811.2XP_038942739.1  unconventional myosin-Ic isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQN4, A0A8L2QFL2
      Related
      ENSRNOP00000080420.1, ENSRNOT00000108756.2
      Conserved Domains (3) summary
      smart00015
      Location:678698
      IQ; Calmodulin-binding motif
      cd01378
      Location:39640
      MYSc_Myo1; class I myosin, motor domain
      pfam06017
      Location:796977
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
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