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    P2ry4 pyrimidinergic receptor P2Y4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63843, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2ry4provided by RGD
    Official Full Name
    pyrimidinergic receptor P2Y4provided by RGD
    Primary source
    RGD:61798
    See related
    EnsemblRapid:ENSRNOG00000070777 AllianceGenome:RGD:61798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P2Y4
    Summary
    Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 16.9), Lung (RPKM 14.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See P2ry4 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (69722604..69757726, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (65681680..65717404, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (70421599..70447109, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol O-acyltransferase 2-like 6 Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene arrestin 3 Neighboring gene uncharacterized LOC120099344 Neighboring gene PDZ domain containing 11 Neighboring gene kinesin family member 4A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in plasma membrane  
    is_active_in presynaptic active zone membrane PubMed 

    General protein information

    Preferred Names
    P2Y purinoceptor 4
    Names
    P2Y ATP receptor 4
    purinergic receptor P2Y, G-protein coupled 4
    pyrimidinergic receptor P2Y, G-protein coupled, 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031680.1NP_113868.1  P2Y purinoceptor 4

      See identical proteins and their annotated locations for NP_113868.1

      Status: PROVISIONAL

      Source sequence(s)
      Y11433
      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000100377.1, ENSRNOT00000133132.1
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      69722604..69757726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100015.2XP_038955943.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111152.1, ENSRNOT00000125396.1
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_039100012.2XP_038955940.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. XM_063280275.1XP_063136345.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
    4. XM_039100009.2XP_038955937.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. XM_039100014.2XP_038955942.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. XM_039100011.2XP_038955939.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    7. XM_063280274.1XP_063136344.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111265.1, ENSRNOT00000167412.1
    8. XM_039100007.2XP_038955935.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. XM_063280276.1XP_063136346.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000082634.1, ENSRNOT00000112073.2
    10. XM_039100006.2XP_038955934.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000104440.1, ENSRNOT00000121214.1
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
    11. XM_063280273.1XP_063136343.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000102816.1, ENSRNOT00000147730.1
    12. XM_039100005.2XP_038955933.1  P2Y purinoceptor 4 isoform X1

      UniProtKB/Swiss-Prot
      O35811
      UniProtKB/TrEMBL
      A6IQ78
      Related
      ENSRNOP00000111264.1, ENSRNOT00000134670.1
      Conserved Domains (1) summary
      cd15374
      Location:32313
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
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