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    Nup62 nucleoporin 62 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65274, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nup62provided by RGD
    Official Full Name
    nucleoporin 62provided by RGD
    Primary source
    RGD:619938
    See related
    EnsemblRapid:ENSRNOG00000048733 AllianceGenome:RGD:619938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Np62
    Summary
    Enables kinesin binding activity. A structural constituent of nuclear pore. Involved in protein import into nucleus; regulation of protein import into nucleus; and spermatogenesis. Located in annulate lamellae and nuclear membrane. Part of nuclear pore. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 126.7), Testes (RPKM 108.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nup62 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104435532..104451392)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95298995..95314902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100811140..100827119)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 473 Neighboring gene VRK serine/threonine kinase 3 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1 Neighboring gene TBC1 domain family, member 17 Neighboring gene AKT1 substrate 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding  
    enables Hsp90 protein binding  
    enables PTB domain binding  
    enables SH2 domain binding  
    enables SH2 domain binding  
    enables kinesin binding PubMed 
    enables nuclear thyroid hormone receptor binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables signaling receptor complex adaptor activity  
    enables signaling receptor complex adaptor activity  
    enables structural constituent of nuclear pore  
    enables structural constituent of nuclear pore PubMed 
    enables ubiquitin binding  
    enables ubiquitin binding  
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in RNA export from nucleus  
    involved_in cell surface receptor signaling pathway  
    involved_in cell surface receptor signaling pathway  
    acts_upstream_of_or_within cellular senescence  
    involved_in centriole assembly  
    involved_in centrosome cycle  
    involved_in mRNA transport  
    involved_in mitotic centrosome separation  
    involved_in mitotic metaphase chromosome alignment  
    involved_in negative regulation of MAP kinase activity  
    involved_in negative regulation of Ras protein signal transduction  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of programmed cell death  
    involved_in negative regulation of programmed cell death  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of centriole replication  
    involved_in positive regulation of mitotic cytokinetic process  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of protein localization to centrosome  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus PubMed 
    involved_in regulation of mitotic spindle organization  
    involved_in regulation of protein import into nucleus PubMed 
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in annulate lamellae PubMed 
    located_in centrosome  
    located_in cytoplasm  
    located_in mitotic spindle  
    located_in nuclear envelope  
    located_in nuclear membrane PubMed 
    located_in nuclear membrane  
    part_of nuclear pore PubMed 
    part_of nuclear pore  
    part_of nuclear pore  
    part_of nuclear pore central transport channel  
    located_in nucleoplasm  
    part_of protein-containing complex PubMed 
    part_of ribonucleoprotein complex  
    located_in spindle pole  

    General protein information

    Preferred Names
    nuclear pore glycoprotein p62
    Names
    62 kDa nucleoporin
    nuclear pore glycoprotein 62
    nucleoporin Nup62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023098.2NP_075586.1  nuclear pore glycoprotein p62

      See identical proteins and their annotated locations for NP_075586.1

      Status: VALIDATED

      Source sequence(s)
      BC128709, CK600248
      UniProtKB/Swiss-Prot
      A2VCW0, P17955
      UniProtKB/TrEMBL
      A6JAS7
      Related
      ENSRNOP00000081212.1, ENSRNOT00000117253.2
      Conserved Domains (3) summary
      COG1196
      Location:366520
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05064
      Location:322432
      Nsp1_C; Nsp1-like C-terminal region
      pfam15967
      Location:1189
      Nucleoporin_FG2; Nucleoporin FG repeated region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104435532..104451392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229150.5XP_006229212.1  nuclear pore glycoprotein p62 isoform X1

      See identical proteins and their annotated locations for XP_006229212.1

      UniProtKB/Swiss-Prot
      A2VCW0, P17955
      UniProtKB/TrEMBL
      A6JAS7
      Related
      ENSRNOP00000100099.1, ENSRNOT00000123208.1
      Conserved Domains (3) summary
      COG1196
      Location:366520
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05064
      Location:322432
      Nsp1_C; Nsp1-like C-terminal region
      pfam15967
      Location:1189
      Nucleoporin_FG2; Nucleoporin FG repeated region
    2. XM_006229151.5XP_006229213.1  nuclear pore glycoprotein p62 isoform X1

      See identical proteins and their annotated locations for XP_006229213.1

      UniProtKB/Swiss-Prot
      A2VCW0, P17955
      UniProtKB/TrEMBL
      A6JAS7
      Related
      ENSRNOP00000103918.1, ENSRNOT00000155881.1
      Conserved Domains (3) summary
      COG1196
      Location:366520
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam05064
      Location:322432
      Nsp1_C; Nsp1-like C-terminal region
      pfam15967
      Location:1189
      Nucleoporin_FG2; Nucleoporin FG repeated region
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