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    Ttc9 tetratricopeptide repeat domain 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500689, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ttc9provided by RGD
    Official Full Name
    tetratricopeptide repeat domain 9provided by RGD
    Primary source
    RGD:1565985
    See related
    EnsemblRapid:ENSRNOG00000007254 AllianceGenome:RGD:1565985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565985
    Summary
    Predicted to enable protein folding chaperone. Predicted to be involved in negative regulation of apoptotic process and protein folding. Predicted to act upstream of or within bone development. Predicted to be active in several cellular components, including cytosol; endomembrane system; and mitochondrial envelope. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human TTC9 (tetratricopeptide repeat domain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 125.4), Lung (RPKM 72.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ttc9 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (107064527..107099361)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101333274..101368110)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105364668..105399500)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene disintegrin and metalloproteinase domain-containing protein 21-like Neighboring gene mediator complex subunit 6 Neighboring gene uncharacterized LOC102552530 Neighboring gene uncharacterized LOC134479223 Neighboring gene mitogen-activated protein kinase kinase kinase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein folding chaperone  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone development  
    involved_in negative regulation of apoptotic process  
    involved_in protein folding  
    Component Evidence Code Pubs
    is_active_in cytosol  
    is_active_in endomembrane system  
    is_active_in membrane  
    is_active_in mitochondrial envelope  

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 9A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134731.1NP_001128203.1  tetratricopeptide repeat protein 9A

      See identical proteins and their annotated locations for NP_001128203.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDN6
      Related
      ENSRNOP00000069448.2, ENSRNOT00000087090.3
      Conserved Domains (3) summary
      sd00006
      Location:129158
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:164196
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:126194
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      107064527..107099361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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