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    Adam1a ADAM metallopeptidase domain 1a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56777, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adam1aprovided by RGD
    Official Full Name
    ADAM metallopeptidase domain 1aprovided by RGD
    Primary source
    RGD:621467
    See related
    EnsemblRapid:ENSRNOG00000001347 AllianceGenome:RGD:621467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adam1; PH-30a
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in membrane raft. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM1A (ADAM metallopeptidase domain 1A (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 267.9), Heart (RPKM 181.0) and 9 other tissues See more
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    Genomic context

    See Adam1a in Genome Data Viewer
    Location:
    12q16
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40674460..40680988)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35017433..35020300)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40533731..40536632)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 2 family member Neighboring gene MAPK activated protein kinase 5 Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93473

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metallopeptidase activity PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida  
    involved_in binding of sperm to zona pellucida  
    acts_upstream_of_or_within binding of sperm to zona pellucida  
    involved_in male gonad development  
    involved_in male gonad development PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane  
    located_in membrane PubMed 
    located_in membrane raft  
    located_in membrane raft  
    is_active_in plasma membrane  
    is_active_in sperm head plasma membrane  

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 1
    Names
    ADAM 1
    PH-30 alpha
    a disintegrin and metallopeptidase domain 1a
    a disintegrin and metalloprotease domain 1 (fertilin alpha)
    a disintegrin and metalloproteinase domain 1 (fertilin alpha)
    fertilin alpha
    fertilin subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020078.1NP_064463.1  disintegrin and metalloproteinase domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_064463.1

      Status: PROVISIONAL

      Source sequence(s)
      Y08616
      UniProtKB/Swiss-Prot
      P70505
      Related
      ENSRNOP00000081520.1, ENSRNOT00000001818.7
      Conserved Domains (4) summary
      smart00050
      Location:450522
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:524660
      ACR; ADAM Cysteine-Rich Domain
      pfam01421
      Location:238432
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:79194
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40674460..40680988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271602.1XP_063127672.1  disintegrin and metalloproteinase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSY2, Q66HK9
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