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    Kcna6 potassium voltage-gated channel subfamily A member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64358, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcna6provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A member 6provided by RGD
    Primary source
    RGD:62083
    See related
    EnsemblRapid:ENSRNOG00000052486 AllianceGenome:RGD:62083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv1.6
    Summary
    Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 100.8), Lung (RPKM 7.6) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Kcna6 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161229103..161262352, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159542941..159576189, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159253934..159287193, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350764 Neighboring gene U2 spliceosomal RNA Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in action potential  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport PubMed 
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in protein homooligomerization  
    Component Evidence Code Pubs
    located_in axon  
    located_in axon terminus  
    located_in axon terminus  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    is_active_in membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex PubMed 
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 6
    Names
    RCK2
    kv2
    potassium channel, voltage gated shaker related subfamily A, member 6
    potassium channel-Kv2
    potassium voltage gated channel, shaker related subfamily, member 6
    voltage-gated potassium channel subunit Kv1.6
    voltage-gated potassium channel subunit Kv2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023954.2NP_076444.1  potassium voltage-gated channel subfamily A member 6

      See identical proteins and their annotated locations for NP_076444.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P17659, P19025
      UniProtKB/TrEMBL
      A6ILW1, G3V8L6
      Related
      ENSRNOP00000071895.1, ENSRNOT00000080139.3
      Conserved Domains (4) summary
      smart00225
      Location:43126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:260469
      Ion_trans; Ion transport protein
      pfam02214
      Location:43132
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      161229103..161262352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286664.1XP_063142734.1  potassium voltage-gated channel subfamily A member 6 isoform X1

      UniProtKB/Swiss-Prot
      P17659, P19025
      UniProtKB/TrEMBL
      A6ILW1, G3V8L6
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