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    Chn2 chimerin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84031, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chn2provided by RGD
    Official Full Name
    chimerin 2provided by RGD
    Primary source
    RGD:620140
    See related
    EnsemblRapid:ENSRNOG00000009411 AllianceGenome:RGD:620140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTPase activator activity. Involved in acrosome assembly. Predicted to be located in synapse. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 337.8), Testes (RPKM 218.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Chn2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84478989..84738068)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83148616..83407711)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84423708..84452989)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene carboxypeptidase, vitellogenic-like Neighboring gene uncharacterized LOC120102282 Neighboring gene uncharacterized LOC102553678 Neighboring gene eukaryotic translation elongation factor 1 beta 2, pseudogene 1 Neighboring gene proline rich 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables metal ion binding  
    enables phorbol ester receptor activity PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly  
    involved_in acrosome assembly PubMed 
    involved_in regulation of small GTPase mediated signal transduction  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in membrane  
    located_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    beta-chimaerin
    Names
    beta-chimerin
    chimerin (chimaerin) 2
    rho GTPase-activating protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032084.2NP_114473.2  beta-chimaerin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5Y7G2, A0A8I6A2H3, A6K0U4
      Conserved Domains (3) summary
      cd10352
      Location:52138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275468
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:210270
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      84478989..84738068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108464.2XP_038964392.1  beta-chimaerin isoform X1

      UniProtKB/Swiss-Prot
      Q03070
      Conserved Domains (2) summary
      cd04372
      Location:129322
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:64124
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
    2. XM_063286763.1XP_063142833.1  beta-chimaerin isoform X1

      UniProtKB/Swiss-Prot
      Q03070
    3. XM_039108465.2XP_038964393.1  beta-chimaerin isoform X2

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A6K0U6, G3V773
      Conserved Domains (2) summary
      cd04372
      Location:102295
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:3797
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    4. XM_039108467.2XP_038964395.1  beta-chimaerin isoform X3

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A0A8I5ZYQ0
      Related
      ENSRNOP00000082836.1, ENSRNOT00000112440.2
      Conserved Domains (2) summary
      cd04372
      Location:84277
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:1979
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
    5. XM_039108466.2XP_038964394.1  beta-chimaerin isoform X2

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A6K0U6, G3V773
      Conserved Domains (2) summary
      cd04372
      Location:102295
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:3797
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    6. XM_063286764.1XP_063142834.1  beta-chimaerin isoform X2

      UniProtKB/Swiss-Prot
      Q03070
      UniProtKB/TrEMBL
      A6K0U6, G3V773
      Related
      ENSRNOP00000012655.3, ENSRNOT00000012655.8
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