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    Atf2 activating transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81647, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atf2provided by RGD
    Official Full Name
    activating transcription factor 2provided by RGD
    Primary source
    RGD:621862
    See related
    EnsemblRapid:ENSRNOG00000001597 AllianceGenome:RGD:621862
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cAMP response element binding activity. Involved in several processes, including amelogenesis; positive regulation of neuron apoptotic process; and regulation of transcription by RNA polymerase II. Part of CCAAT-binding activity factor complex. Used to study hypertension and transient cerebral ischemia. Biomarker of glaucoma and transient cerebral ischemia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 253.5), Thymus (RPKM 196.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atf2 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (79125814..79202896, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (58718323..58795280, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (60721137..60795951, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1136 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 4 Neighboring gene ribosomal protein L19, pseudogene 5 Neighboring gene uncharacterized LOC134486116 Neighboring gene uncharacterized LOC120101572 Neighboring gene ATP synthase membrane subunit c locus 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 37
    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables cAMP response element binding  
    enables cAMP response element binding PubMed 
    enables cAMP response element binding  
    enables cAMP response element binding  
    enables cAMP response element binding protein binding  
    enables cAMP response element binding protein binding  
    enables chromatin binding  
    enables cis-regulatory region sequence-specific DNA binding  
    enables histone H2B acetyltransferase activity  
    enables histone H2B acetyltransferase activity  
    enables histone H4 acetyltransferase activity  
    enables histone H4 acetyltransferase activity  
    enables identical protein binding  
    enables leucine zipper domain binding  
    enables leucine zipper domain binding  
    enables metal ion binding  
    enables promoter-specific chromatin binding  
    enables promoter-specific chromatin binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-containing complex binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    Items 1 - 25 of 37
    Items 1 - 25 of 104
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in NK T cell differentiation  
    involved_in NK T cell differentiation  
    involved_in abducens nucleus development  
    involved_in abducens nucleus development  
    involved_in adipose tissue development  
    acts_upstream_of_or_within adipose tissue development  
    involved_in amelogenesis PubMed 
    involved_in apoptotic process  
    involved_in apoptotic process involved in development  
    involved_in apoptotic process involved in development  
    involved_in brainstem development  
    involved_in brainstem development  
    involved_in cellular response to anisomycin  
    involved_in cellular response to anisomycin  
    involved_in cellular response to leucine starvation  
    acts_upstream_of_or_within_positive_effect cellular response to leucine starvation  
    involved_in cellular response to leucine starvation  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to virus  
    involved_in cellular response to virus  
    involved_in detection of cell density  
    involved_in detection of cell density  
    involved_in facial nucleus development  
    involved_in facial nucleus development  
    involved_in gene expression  
    involved_in growth plate cartilage chondrocyte differentiation  
    involved_in growth plate cartilage chondrocyte differentiation  
    involved_in growth plate cartilage chondrocyte proliferation  
    involved_in growth plate cartilage chondrocyte proliferation  
    involved_in heart development  
    involved_in hematopoietic progenitor cell differentiation  
    involved_in hematopoietic progenitor cell differentiation  
    involved_in hepatocyte apoptotic process  
    involved_in hepatocyte apoptotic process  
    involved_in hypoglossal nucleus development  
    involved_in hypoglossal nucleus development  
    involved_in in utero embryonic development  
    involved_in in utero embryonic development  
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia  
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia  
    involved_in liver development  
    involved_in liver development  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mRNA transcription by RNA polymerase II  
    involved_in mitotic intra-S DNA damage checkpoint signaling  
    involved_in mitotic intra-S DNA damage checkpoint signaling  
    involved_in mitotic intra-S DNA damage checkpoint signaling  
    involved_in motor neuron apoptotic process  
    involved_in motor neuron apoptotic process  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neurofilament cytoskeleton organization  
    involved_in neurofilament cytoskeleton organization  
    involved_in outflow tract morphogenesis  
    acts_upstream_of_or_within outflow tract morphogenesis  
    involved_in p38MAPK cascade  
    involved_in p38MAPK cascade  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of DNA-binding transcription factor activity  
    involved_in positive regulation of cardiac muscle myoblast proliferation  
    involved_in positive regulation of cardiac muscle myoblast proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta2 production  
    acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production  
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within_positive_effect regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to organic cyclic compound  
    involved_in response to organic cyclic compound  
    involved_in response to osmotic stress  
    involved_in response to osmotic stress  
    involved_in response to osmotic stress  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in vacuole organization  
    involved_in vacuole organization  
    involved_in white fat cell differentiation  
    acts_upstream_of_or_within white fat cell differentiation  
    involved_in white fat cell differentiation  
    Items 1 - 25 of 104
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex PubMed 
    part_of H4 histone acetyltransferase complex  
    part_of H4 histone acetyltransferase complex  
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex  
    located_in chromatin  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in site of double-strand break  
    located_in site of double-strand break  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-2
    Names
    cAMP response element-binding protein CRE-BP1
    cAMP-dependent transcription factor ATF-2
    NP_112280.1
    XP_038961844.1
    XP_063140694.1
    XP_063140695.1
    XP_063140696.1
    XP_063140697.1
    XP_063140698.1
    XP_063140699.1
    XP_063140700.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031018.2NP_112280.1  cyclic AMP-dependent transcription factor ATF-2

      See identical proteins and their annotated locations for NP_112280.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q00969, Q62870
      UniProtKB/TrEMBL
      A6HMA9, A6HMB2
      Related
      ENSRNOP00000101448.1, ENSRNOT00000157814.1
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      79125814..79202896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284626.1XP_063140696.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q100, A6HMB1, A6HMB2
      Related
      ENSRNOP00000002174.6, ENSRNOT00000002174.9
    2. XM_063284629.1XP_063140699.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    3. XM_039105916.2XP_038961844.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

      Related
      ENSRNOP00000046001.3, ENSRNOT00000050513.6
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_063284625.1XP_063140695.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      UniProtKB/Swiss-Prot
      Q00969, Q62870
      UniProtKB/TrEMBL
      A6HMA9, A6HMB2
    5. XM_063284630.1XP_063140700.1  cyclic AMP-dependent transcription factor ATF-2 isoform X4

    6. XM_063284628.1XP_063140698.1  cyclic AMP-dependent transcription factor ATF-2 isoform X3

    7. XM_063284627.1XP_063140697.1  cyclic AMP-dependent transcription factor ATF-2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q100, A6HMB1, A6HMB2
    8. XM_063284624.1XP_063140694.1  cyclic AMP-dependent transcription factor ATF-2 isoform X1

      UniProtKB/Swiss-Prot
      Q00969, Q62870
      UniProtKB/TrEMBL
      A6HMA9, A6HMB2
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