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    Slc6a9 solute carrier family 6 member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116509, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc6a9provided by RGD
    Official Full Name
    solute carrier family 6 member 9provided by RGD
    Primary source
    RGD:621243
    See related
    EnsemblRapid:ENSRNOG00000019484 AllianceGenome:RGD:621243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glyt1; GLYT-1; GLYT-1b
    Summary
    Enables glycine:sodium symporter activity. Involved in glycine import across plasma membrane. Located in dense core granule; endosome; and plasma membrane. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 173.1), Liver (RPKM 105.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Slc6a9 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136660022..136694173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131374562..131408733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136669674..136703702)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486978 Neighboring gene KLF transcription factor 17 Neighboring gene uncharacterized LOC120102957 Neighboring gene coiled-coil domain containing 24 Neighboring gene beta-1,4-galactosyltransferase 2 Neighboring gene ATPase H+ transporting V0 subunit B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport  
    involved_in glycine import across plasma membrane  
    involved_in glycine import across plasma membrane PubMed 
    involved_in glycine import across plasma membrane  
    acts_upstream_of_or_within glycine secretion, neurotransmission  
    acts_upstream_of_or_within glycine transport  
    involved_in glycine transport  
    acts_upstream_of negative regulation of NMDA glutamate receptor activity  
    involved_in neurotransmitter transport  
    involved_in neurotransmitter uptake  
    involved_in positive regulation of heme biosynthetic process  
    involved_in positive regulation of hemoglobin biosynthetic process  
    involved_in regulation of synaptic transmission, glycinergic  
    involved_in regulation of synaptic transmission, glycinergic  
    involved_in sodium ion transmembrane transport  
    involved_in sodium ion transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    is_active_in asymmetric synapse PubMed 
    located_in basal plasma membrane  
    located_in basolateral plasma membrane  
    located_in dense core granule PubMed 
    located_in endosome PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
    located_in lateral plasma membrane  
    is_active_in parallel fiber to Purkinje cell synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density PubMed 
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in synaptic vesicle membrane PubMed 

    General protein information

    Preferred Names
    sodium- and chloride-dependent glycine transporter 1
    Names
    glycine transporter 1
    solute carrier family 6 (neurotransmitter transporter, glycine), member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053818.3NP_446270.1  sodium- and chloride-dependent glycine transporter 1

      See identical proteins and their annotated locations for NP_446270.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JZE5
      Related
      ENSRNOP00000040252.4, ENSRNOT00000048770.5
      Conserved Domains (1) summary
      cd11498
      Location:11594
      SLC6sbd_GlyT1; Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      136660022..136694173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109142.2XP_038965070.1  sodium- and chloride-dependent glycine transporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2ULJ7
      Conserved Domains (1) summary
      cl00456
      Location:26556
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006238625.5XP_006238687.1  sodium- and chloride-dependent glycine transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006238687.1

      UniProtKB/Swiss-Prot
      A1A5N0, P28572, Q63322, Q63323
      Related
      ENSRNOP00000070161.1, ENSRNOT00000085527.3
      Conserved Domains (1) summary
      cd11498
      Location:16599
      SLC6sbd_GlyT1; Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain
    3. XM_039109143.2XP_038965071.1  sodium- and chloride-dependent glycine transporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2ULJ7
      Conserved Domains (1) summary
      cl00456
      Location:26556
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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