Csf2rb colony stimulating factor 2 receptor subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csf2rbprovided by RGD
Official Full Name: colony stimulating factor 2 receptor subunit betaprovided by RGD
Primary source: RGD:620189
See related: EnsemblRapid:ENSRNOG00000000187 AllianceGenome:RGD:620189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Csf2rb1
Summary: Predicted to enable coreceptor activity and cytokine receptor activity. Involved in response to lipopolysaccharide. Predicted to be part of granulocyte macrophage colony-stimulating factor receptor complex. Predicted to be active in external side of plasma membrane. Used to study asthma. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human CSF2RB (colony stimulating factor 2 receptor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 294.9), Spleen (RPKM 102.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (111756950..111782089)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (109876919..109901589)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (119554383..119568248)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of granulocyte macrophage colony-stimulating factor receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytokine receptor common subunit beta

Names: colony stimulating factor 2 receptor beta common subunit; colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macrophage); colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); interleukin 3 common beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133555.1 → NP_598239.1 cytokine receptor common subunit beta precursor

See identical proteins and their annotated locations for NP_598239.1

Status: PROVISIONAL

Source sequence(s)

AJ000555

UniProtKB/TrEMBL

A0A8I6GE59, Q78ZF5

Conserved Domains (3) summary

smart00060
Location:136 → 224

FN3; Fibronectin type 3 domain

cd00063
Location:344 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:248 → 326

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

111756950..111782089

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078342.2 → XP_038934270.1 cytokine receptor common subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I6GE59, A6HSJ2, G3V608

Conserved Domains (2) summary

smart00060
Location:136 → 224

FN3; Fibronectin type 3 domain

cd00063
Location:344 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039078343.2 → XP_038934271.1 cytokine receptor common subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I6GE59, A6HSJ2, G3V608

Related

ENSRNOP00000000203.6, ENSRNOT00000000203.7

Conserved Domains (2) summary

smart00060
Location:136 → 224

FN3; Fibronectin type 3 domain

cd00063
Location:344 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039078344.2 → XP_038934272.1 cytokine receptor common subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I6GE59, A6HSJ2, G3V608

Conserved Domains (2) summary

smart00060
Location:136 → 224

FN3; Fibronectin type 3 domain

cd00063
Location:344 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...