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    Srcin1 SRC kinase signaling inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56029, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srcin1provided by RGD
    Official Full Name
    SRC kinase signaling inhibitor 1provided by RGD
    Primary source
    RGD:708439
    See related
    EnsemblRapid:ENSRNOG00000011475 AllianceGenome:RGD:708439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P140; Snip; p140Cap
    Summary
    Enables protein domain specific binding activity. Involved in negative regulation of protein secretion. Located in several cellular components, including filopodium; lamellipodium; and postsynaptic density. Is active in postsynapse and presynapse. Orthologous to human SRCIN1 (SRC kinase signaling inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 68.0), Testes (RPKM 43.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Srcin1 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82999295..83066359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82502911..82569882, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85460059..85517671, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 7 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC134480864 Neighboring gene uncharacterized LOC102548331 Neighboring gene uncharacterized LOC134480715 Neighboring gene elongin BC and polycomb repressive complex 2 associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    Process Evidence Code Pubs
    involved_in exocytosis  
    acts_upstream_of_or_within negative regulation of cell adhesion  
    involved_in negative regulation of protein secretion PubMed 
    involved_in negative regulation of protein tyrosine kinase activity  
    involved_in negative regulation of protein tyrosine kinase activity  
    involved_in positive regulation of protein tyrosine kinase activity  
    involved_in positive regulation of protein tyrosine kinase activity  
    involved_in postsynaptic actin cytoskeleton organization  
    involved_in postsynaptic actin cytoskeleton organization  
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of dendritic spine morphogenesis  
    involved_in regulation of dendritic spine morphogenesis  
    involved_in regulation of dendritic spine morphogenesis  
    involved_in regulation of dendritic spine morphogenesis  
    involved_in regulation of synapse assembly  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    located_in actin cytoskeleton PubMed 
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in filopodium PubMed 
    NOT located_in focal adhesion  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in lamellipodium PubMed 
    located_in neuronal cell body PubMed 
    is_active_in postsynapse PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density PubMed 
    located_in postsynaptic density  
    is_active_in presynapse PubMed 
    is_active_in presynapse  
    located_in synapse PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    SRC kinase signaling inhibitor 1
    Names
    SNAP25-interacting protein
    p130Cas-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393740.2NP_001380669.1  SRC kinase signaling inhibitor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AEP4
      Related
      ENSRNOP00000083677.2, ENSRNOT00000108672.2
      Conserved Domains (2) summary
      smart00806
      Location:218289
      AIP3; Actin interacting protein 3
      TIGR02169
      Location:719873
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    2. NM_001393741.2NP_001380670.1  SRC kinase signaling inhibitor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AEP4, A6HIK5
      Related
      ENSRNOP00000099638.1, ENSRNOT00000153078.1
      Conserved Domains (2) summary
      TIGR02169
      Location:720874
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03915
      Location:219316
      AIP3; Actin interacting protein 3
    3. NM_019378.3NP_062251.1  SRC kinase signaling inhibitor 1 isoform 2

      See identical proteins and their annotated locations for NP_062251.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9QXY2, Q9QXY3
      UniProtKB/TrEMBL
      A0A8I6AEP4, A6HIK6
      Conserved Domains (1) summary
      pfam03915
      Location:219290
      AIP3; Actin interacting protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82999295..83066359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269719.1XP_063125789.1  SRC kinase signaling inhibitor 1 isoform X13

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    2. XM_063269720.1XP_063125790.1  SRC kinase signaling inhibitor 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000016070.6, ENSRNOT00000016070.8
    3. XM_063269708.1XP_063125778.1  SRC kinase signaling inhibitor 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    4. XM_063269716.1XP_063125786.1  SRC kinase signaling inhibitor 1 isoform X10

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    5. XM_063269711.1XP_063125781.1  SRC kinase signaling inhibitor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000102162.1, ENSRNOT00000121767.1
    6. XM_063269714.1XP_063125784.1  SRC kinase signaling inhibitor 1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000105332.1, ENSRNOT00000166888.1
    7. XM_063269712.1XP_063125782.1  SRC kinase signaling inhibitor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q7U5
      Related
      ENSRNOP00000080321.2, ENSRNOT00000099263.2
    8. XM_063269709.1XP_063125779.1  SRC kinase signaling inhibitor 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    9. XM_063269710.1XP_063125780.1  SRC kinase signaling inhibitor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    10. XM_063269713.1XP_063125783.1  SRC kinase signaling inhibitor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    11. XM_063269707.1XP_063125777.1  SRC kinase signaling inhibitor 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    12. XM_063269723.1XP_063125793.1  SRC kinase signaling inhibitor 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AEP4
      Related
      ENSRNOP00000095793.2, ENSRNOT00000109362.2
    13. XM_063269730.1XP_063125800.1  SRC kinase signaling inhibitor 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6AEP4
    14. XM_063269722.1XP_063125792.1  SRC kinase signaling inhibitor 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I6AEP4
    15. XM_063269729.1XP_063125799.1  SRC kinase signaling inhibitor 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AEP4
    16. XM_063269727.1XP_063125797.1  SRC kinase signaling inhibitor 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6AEP4
    17. XM_063269726.1XP_063125796.1  SRC kinase signaling inhibitor 1 isoform X20

      UniProtKB/TrEMBL
      A0A8I6AEP4
    18. XM_063269731.1XP_063125801.1  SRC kinase signaling inhibitor 1 isoform X25

      UniProtKB/TrEMBL
      A0A8I6AEP4
    19. XM_063269721.1XP_063125791.1  SRC kinase signaling inhibitor 1 isoform X15

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    20. XM_063269717.1XP_063125787.1  SRC kinase signaling inhibitor 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZQE0
    21. XM_063269715.1XP_063125785.1  SRC kinase signaling inhibitor 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZQE0
    22. XM_063269718.1XP_063125788.1  SRC kinase signaling inhibitor 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZQE0
      Related
      ENSRNOP00000104199.1, ENSRNOT00000127145.1
    23. XM_063269725.1XP_063125795.1  SRC kinase signaling inhibitor 1 isoform X19

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    24. XM_063269736.1XP_063125806.1  SRC kinase signaling inhibitor 1 isoform X29

      UniProtKB/TrEMBL
      A0A8I6AKG9
    25. XM_063269734.1XP_063125804.1  SRC kinase signaling inhibitor 1 isoform X27

      UniProtKB/TrEMBL
      A0A8I6AKG9
    26. XM_063269735.1XP_063125805.1  SRC kinase signaling inhibitor 1 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AKG9
    27. XM_063269732.1XP_063125802.1  SRC kinase signaling inhibitor 1 isoform X26

      UniProtKB/TrEMBL
      A0A8I6AKG9
    28. XM_063269724.1XP_063125794.1  SRC kinase signaling inhibitor 1 isoform X18

      UniProtKB/TrEMBL
      A0A8L2Q7U5
    29. XM_063269728.1XP_063125798.1  SRC kinase signaling inhibitor 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AEP4

    RNA

    1. XR_010055230.1 RNA Sequence

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