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    Adam18 ADAM metallopeptidase domain 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam18provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 18provided by RGD
    Primary source
    RGD:620405
    See related
    EnsemblRapid:ENSRNOG00000017683 AllianceGenome:RGD:620405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    tMDCIII
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in cell differentiation; proteolysis; and spermatogenesis. Predicted to be located in membrane. Orthologous to human ADAM18 (ADAM metallopeptidase domain 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 36.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam18 in Genome Data Viewer
    Location:
    16q12.4-q12.5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (74054974..74127861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67352360..67425820)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72139100..72210902)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 5 Neighboring gene ADAM metallopeptidase domain 3A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108348416 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene indoleamine 2,3-dioxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human tMDC III: a sperm protein with a potential role in oocyte recognition. Frayne J, et al. Mol Hum Reprod, 2002 Sep. PMID 12200459
    2. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
    3. Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract. Frayne J, et al. Mol Hum Reprod, 1998 May. PMID 9665629
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 18
    Names
    ADAM 18
    a disintegrin and metallopeptidase domain 18
    a disintegrin and metalloproteinase domain 18
    tMDC III
    transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001375316.1 → NP_001362245.1  disintegrin and metalloproteinase domain-containing protein 18 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW32
      Related
      ENSRNOP00000102015.1, ENSRNOT00000126997.1
      Conserved Domains (4) summary
      smart00608
      Location:473 → 611
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:181 → 374
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:394 → 469
      Disintegrin
      pfam01562
      Location:25 → 140
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      74054974..74127861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094795.2 → XP_038950723.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

      UniProtKB/TrEMBL
      A6IW32, F1LRY9
      Conserved Domains (4) summary
      smart00608
      Location:507 → 645
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:215 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:428 → 503
      Disintegrin
      pfam01562
      Location:59 → 174
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_039094796.2 → XP_038950724.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X3

      UniProtKB/TrEMBL
      A6IW32
      Conserved Domains (4) summary
      smart00608
      Location:507 → 645
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:215 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:428 → 503
      Disintegrin
      pfam01562
      Location:59 → 174
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_039094794.2 → XP_038950722.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X1

      UniProtKB/TrEMBL
      A6IW32, F1LRY9
      Related
      ENSRNOP00000023805.6, ENSRNOT00000023805.9
      Conserved Domains (4) summary
      smart00608
      Location:507 → 645
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:215 → 408
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:428 → 503
      Disintegrin
      pfam01562
      Location:59 → 174
      Pep_M12B_propep; Reprolysin family propeptide

    4. XM_063275669.1 → XP_063131739.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X2

      UniProtKB/TrEMBL
      A6IW32
      Related
      ENSRNOP00000102798.1, ENSRNOT00000140869.1

    5. XM_063275670.1 → XP_063131740.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X4

      UniProtKB/TrEMBL
      A6IW32

    6. XM_063275671.1 → XP_063131741.1  disintegrin and metalloproteinase domain-containing protein 18 isoform X5

      UniProtKB/TrEMBL
      A6IW32

    RNA

    1. XR_005494666.2 RNA Sequence

    2. XR_010058314.1 RNA Sequence

    3. XR_010058313.1 RNA Sequence

    4. XR_010058312.1 RNA Sequence

    5. XR_010058316.1 RNA Sequence

    6. XR_010058315.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97776.1 GenPept UniProtKB/Swiss-Prot:P97776

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.