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    Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373545, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkag2provided by RGD
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit gamma 2provided by RGD
    Primary source
    RGD:727782
    See related
    EnsemblRapid:ENSRNOG00000009085 AllianceGenome:RGD:727782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables AMP binding activity and protein kinase binding activity. Contributes to AMP-activated protein kinase activity. Involved in regulation of catalytic activity. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 35.3), Brain (RPKM 28.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prkag2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (10744695..10985939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10010890..10252155)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (6559153..6799888)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene lysine methyltransferase 2C Neighboring gene calcineurin B homologous protein 1-like Neighboring gene hypothetical LOC100359776 Neighboring gene uncharacterized LOC102554253 Neighboring gene uncharacterized LOC102554193 Neighboring gene uncharacterized LOC120102471 Neighboring gene Ras homolog, mTORC1 binding Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to AMP-activated protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphorylase kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-2
    Names
    AMP-activated protein kinase gamma2 subunit
    AMPK gamma 2
    adenosine monophosphate-activated protein kinase gamma 2-subunit
    protein kinase, AMP-activated, gamma 2 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398879.1NP_001385808.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5Y6F6
      Conserved Domains (2) summary
      cd04618
      Location:266403
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:429552
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    2. NM_184051.1NP_908940.1  5'-AMP-activated protein kinase subunit gamma-2 isoform 2

      See identical proteins and their annotated locations for NP_908940.1

      Status: PROVISIONAL

      Source sequence(s)
      AY348865
      UniProtKB/TrEMBL
      A6KJH6, F1LM70, Q6V7V4
      Conserved Domains (3) summary
      COG0517
      Location:192308
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:35164
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:191310
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      10744695..10985939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235951.4XP_006236013.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X5

      UniProtKB/TrEMBL
      A0A140UHX4, A0A8I5Y6F6
      Related
      ENSRNOP00000062361.4, ENSRNOT00000067183.5
      Conserved Domains (3) summary
      COG0517
      Location:433549
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:276405
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:432551
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    2. XM_063286390.1XP_063142460.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X8

      UniProtKB/TrEMBL
      Q4QRB9
    3. XM_063286391.1XP_063142461.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X9

      UniProtKB/TrEMBL
      Q4QRB9
    4. XM_006235949.4XP_006236011.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6F6
      Conserved Domains (3) summary
      COG0517
      Location:433549
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:276405
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:432551
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    5. XM_063286389.1XP_063142459.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y6F6
    6. XM_017592729.3XP_017448218.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y6F6
    7. XM_017592730.3XP_017448219.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y6F6
    8. XM_039107960.2XP_038963888.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y6F6
      Conserved Domains (2) summary
      cd04618
      Location:218355
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:381479
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    9. XM_017592731.3XP_017448220.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6F6
    10. XM_039107963.2XP_038963891.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X12

      UniProtKB/TrEMBL
      Q4QRB9
      Conserved Domains (2) summary
      cd04618
      Location:115252
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:278376
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    11. XM_017592732.3XP_017448221.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X10

    12. XM_063286392.1XP_063142462.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X11

      UniProtKB/TrEMBL
      Q4QRB9
    13. XM_006235955.5XP_006236017.2  5'-AMP-activated protein kinase subunit gamma-2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZQR3, Q4QRB9
      Related
      ENSRNOP00000080463.1, ENSRNOT00000106083.2
    14. XM_063286393.1XP_063142463.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X14

      UniProtKB/TrEMBL
      Q4QRB9
    15. XM_063286396.1XP_063142466.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X17

      UniProtKB/TrEMBL
      A6KJH6
    16. XM_063286398.1XP_063142468.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X21

      UniProtKB/TrEMBL
      A6KJH6, F1LM70, Q6V7V4
    17. XM_063286394.1XP_063142464.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X15

    18. XM_063286395.1XP_063142465.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X16

    19. XM_063286397.1XP_063142467.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X20

      UniProtKB/TrEMBL
      A6KJH6
    20. XM_063286399.1XP_063142469.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X22

      UniProtKB/TrEMBL
      A6KJH6
    21. XM_063286400.1XP_063142470.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X23

      UniProtKB/TrEMBL
      A6KJH6
    22. XM_039107964.2XP_038963892.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X18

      Conserved Domains (2) summary
      cd04618
      Location:25162
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:188286
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    23. XM_039107965.2XP_038963893.1  5'-AMP-activated protein kinase subunit gamma-2 isoform X19

      Conserved Domains (2) summary
      cd04618
      Location:24161
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:187285
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase