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    Exog exo/endonuclease G [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301062, updated on 9-Dec-2024

    Summary

    Official Symbol
    Exogprovided by RGD
    Official Full Name
    exo/endonuclease Gprovided by RGD
    Primary source
    RGD:1304628
    See related
    EnsemblRapid:ENSRNOG00000014801 AllianceGenome:RGD:1304628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Endogl1
    Summary
    Predicted to enable 5'-3' exonuclease activity; RNA endonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 27.7), Brain (RPKM 24.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Exog in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128062688..128082529)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119184974..119204819)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128133398..128153110)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene activin A receptor type 2B Neighboring gene 40S ribosomal protein S27-like Neighboring gene sodium voltage-gated channel alpha subunit 5 Neighboring gene uncharacterized LOC134480113 Neighboring gene sodium voltage-gated channel alpha subunit 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity  
    enables 5'-3' exonuclease activity  
    enables RNA endonuclease activity  
    enables endonuclease activity  
    enables metal ion binding  
    enables nucleic acid binding  
    enables single-stranded DNA endodeoxyribonuclease activity  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrion  
    is_active_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    nuclease EXOG, mitochondrial
    Names
    endo/exonuclease (5'-3'), endonuclease G-like
    endonuclease G-like 1
    NP_001100336.1
    XP_006244150.2
    XP_038937228.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106866.3NP_001100336.1  nuclease EXOG, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001100336.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I3W8, A6I3W9, D3ZTW9
      Related
      ENSRNOP00000020174.4, ENSRNOT00000020174.7
      Conserved Domains (1) summary
      smart00477
      Location:77286
      NUC; DNA/RNA non-specific endonuclease

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128062688..128082529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244088.4XP_006244150.2  nuclease EXOG, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6I3W8
      Related
      ENSRNOP00000111424.1, ENSRNOT00000131964.1
      Conserved Domains (2) summary
      smart00477
      Location:152361
      NUC; DNA/RNA non-specific endonuclease
      pfam18026
      Location:377425
      Exog_C; Endo/exonuclease (EXOG) C-terminal domain
    2. XM_039081300.2XP_038937228.1  nuclease EXOG, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6I3X2, A6I3X3
      Conserved Domains (2) summary
      pfam18026
      Location:149197
      Exog_C; Endo/exonuclease (EXOG) C-terminal domain
      cl00089
      Location:1133
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
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