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    Impact impact RWD domain protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497198, updated on 9-Dec-2024

    Summary

    Official Symbol
    Impactprovided by RGD
    Official Full Name
    impact RWD domain proteinprovided by RGD
    Primary source
    RGD:1591977
    See related
    EnsemblRapid:ENSRNOG00000045844 AllianceGenome:RGD:1591977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; protein sequestering activity; and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 814.8), Thymus (RPKM 267.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Impact in Genome Data Viewer
    Location:
    18p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4383546..4422280)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (4108872..4147571)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4325872..4346734)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene uncharacterized LOC102546723 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene uncharacterized LOC134482907 Neighboring gene histamine receptor H4

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding  
    enables protein sequestering activity  
    enables protein sequestering activity  
    enables ribosome binding  
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling  
    involved_in GCN2-mediated signaling  
    involved_in GCN2-mediated signaling  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within negative regulation of protein phosphorylation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of neuron differentiation  
    involved_in regulation of cytoplasmic translational initiation in response to stress  
    involved_in regulation of cytoplasmic translational initiation in response to stress  
    involved_in regulation of translation  
    involved_in regulation of translational initiation  
    acts_upstream_of_or_within regulation of translational initiation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    protein IMPACT
    Names
    imprinted and ancient gene protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012235.1NP_001012235.1  protein IMPACT

      See identical proteins and their annotated locations for NP_001012235.1

      Status: PROVISIONAL

      Source sequence(s)
      AY574213
      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
      Related
      ENSRNOP00000102236.1, ENSRNOT00000121832.1
      Conserved Domains (2) summary
      smart00591
      Location:15115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:180285
      UPF0029; Uncharacterized protein family UPF0029

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      4383546..4422280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277509.1XP_063133579.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
    2. XM_063277511.1XP_063133581.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
    3. XM_063277510.1XP_063133580.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
    4. XM_063277512.1XP_063133582.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
    5. XM_039097018.2XP_038952946.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
      Related
      ENSRNOP00000078372.1, ENSRNOT00000116602.2
      Conserved Domains (2) summary
      smart00591
      Location:15115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:180285
      UPF0029; Uncharacterized protein family UPF0029
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