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    Cnot2 CCR4-NOT transcription complex, subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299805, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cnot2provided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 2provided by RGD
    Primary source
    RGD:1311672
    See related
    EnsemblRapid:ENSRNOG00000004909 AllianceGenome:RGD:1311672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of macromolecule biosynthetic process; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 397.7), Kidney (RPKM 240.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cnot2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54016447..54117511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52130445..52222338, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59526105..59617307, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, B Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 4 Neighboring gene protein disulfide isomerase family A, member 4, pseudogene 1 Neighboring gene uncharacterized LOC120093596

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of CCR4-NOT complex  
    part_of CCR4-NOT core complex  
    is_active_in P-body  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399553.1NP_001386482.1  CCR4-NOT transcription complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5Y9U2, A0A8I6AJD1
    2. NM_001399554.1NP_001386483.1  CCR4-NOT transcription complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AJD1
      Related
      ENSRNOP00000077944.2, ENSRNOT00000114739.2
    3. NM_001399555.1NP_001386484.1  CCR4-NOT transcription complex subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KB82, A0A8I6AJD1
      Related
      ENSRNOP00000078367.2, ENSRNOT00000100132.2
    4. NM_001399556.1NP_001386485.1  CCR4-NOT transcription complex subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IGN5, A6IGP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54016447..54117511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078732.2XP_038934660.1  CCR4-NOT transcription complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A6IGN0
      Conserved Domains (1) summary
      pfam04153
      Location:228351
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    2. XM_006241369.4XP_006241431.1  CCR4-NOT transcription complex subunit 2 isoform X3

      See identical proteins and their annotated locations for XP_006241431.1

      UniProtKB/TrEMBL
      A0A8I6AJD1
      Related
      ENSRNOP00000084380.2, ENSRNOT00000104908.2
      Conserved Domains (1) summary
      pfam04153
      Location:365488
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    3. XM_039078728.2XP_038934656.1  CCR4-NOT transcription complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A6IGN1
      Conserved Domains (1) summary
      pfam04153
      Location:269392
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    4. XM_039078720.2XP_038934648.1  CCR4-NOT transcription complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB82, A0A8I6AJD1
      Conserved Domains (1) summary
      pfam04153
      Location:387510
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    5. XM_017594741.3XP_017450230.1  CCR4-NOT transcription complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZXR1, A6IGN2
      Conserved Domains (1) summary
      pfam04153
      Location:355478
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    6. XM_039078730.2XP_038934658.1  CCR4-NOT transcription complex subunit 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKS1, A6IGN1
      Conserved Domains (1) summary
      pfam04153
      Location:259382
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    7. XM_039078717.2XP_038934645.1  CCR4-NOT transcription complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJD1
      Conserved Domains (1) summary
      pfam04153
      Location:396519
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    8. XM_063263224.1XP_063119294.1  CCR4-NOT transcription complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A6IGN2, A6IGP0
      Related
      ENSRNOP00000061277.1, ENSRNOT00000066396.4
    9. XM_039078735.2XP_038934663.1  CCR4-NOT transcription complex subunit 2 isoform X11

      UniProtKB/TrEMBL
      A6IGP2
      Conserved Domains (1) summary
      pfam04153
      Location:136259
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    10. XM_063263225.1XP_063119295.1  CCR4-NOT transcription complex subunit 2 isoform X9

    11. XM_063263226.1XP_063119296.1  CCR4-NOT transcription complex subunit 2 isoform X10

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