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    Lcn2 lipocalin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170496, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lcn2provided by RGD
    Official Full Name
    lipocalin 2provided by RGD
    Primary source
    RGD:69408
    See related
    EnsemblRapid:ENSRNOG00000013973 AllianceGenome:RGD:69408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sip24
    Summary
    Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of hippocampal neuron apoptotic process. Located in extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; transient cerebral ischemia; and traumatic brain injury. Human ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 27.4), Lung (RPKM 18.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Lcn2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36078432..36081851, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15680688..15684033, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11414189..11417534, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486070 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene uncharacterized LOC120101523 Neighboring gene prostaglandin E synthase 2 Neighboring gene solute carrier family 25 member 25 Neighboring gene nuclear apoptosis inducing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enterobactin binding PubMed 
    enables enterobactin binding  
    enables enterobactin binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables iron ion binding  
    enables iron ion binding  
    enables iron ion sequestering activity  
    enables iron ion sequestering activity  
    enables protease binding PubMed 
    enables small molecule binding  
    Items 1 - 25 of 49
    Process Evidence Code Pubs
    involved_in acute-phase response PubMed 
    involved_in cellular response to X-ray PubMed 
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to increased oxygen levels PubMed 
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to interleukin-6 PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to nutrient levels PubMed 
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in defense response to bacterium  
    involved_in defense response to bacterium  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in innate immune response  
    involved_in innate immune response  
    involved_in long-term memory PubMed 
    involved_in negative regulation of hippocampal neuron apoptotic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of cell projection organization PubMed 
    involved_in positive regulation of cold-induced thermogenesis  
    involved_in positive regulation of cold-induced thermogenesis PubMed 
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of endothelial tube morphogenesis PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of hippocampal neuron apoptotic process PubMed 
    involved_in positive regulation of iron ion import across plasma membrane PubMed 
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process PubMed 
    involved_in response to bacterium PubMed 
    acts_upstream_of_or_within response to bacterium  
    involved_in response to blue light PubMed 
    involved_in response to fructose PubMed 
    involved_in response to herbicide PubMed 
    involved_in response to iron(II) ion PubMed 
    involved_in response to kainic acid PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to mycotoxin PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in response to toxic substance PubMed 
    acts_upstream_of_or_within response to virus  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in short-term memory PubMed 
    involved_in siderophore transport  
    involved_in siderophore transport  
    Items 1 - 25 of 49
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle lumen  
    located_in extracellular region  
    located_in extracellular region  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    General protein information

    Preferred Names
    neutrophil gelatinase-associated lipocalin
    Names
    NGAL
    alpha-2-microglobulin-related protein
    alpha-2U globulin-related protein
    lipocalin 2 (oncogene 24p3)
    lipocalin 24p3
    p25
    siderocalin LCN2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130741.2NP_570097.2  neutrophil gelatinase-associated lipocalin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P30152, Q5HZF1
      UniProtKB/TrEMBL
      A6JU59
      Related
      ENSRNOP00000018776.3, ENSRNOT00000018776.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36078432..36081851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283026.1XP_063139096.1  neutrophil gelatinase-associated lipocalin isoform X2

    2. XM_063283025.1XP_063139095.1  neutrophil gelatinase-associated lipocalin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNE2
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