U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Gna11 G protein subunit alpha 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81662, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gna11provided by RGD
    Official Full Name
    G protein subunit alpha 11provided by RGD
    Primary source
    RGD:619749
    See related
    EnsemblRapid:ENSRNOG00000005446 AllianceGenome:RGD:619749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg1k
    Summary
    Enables alkylglycerophosphoethanolamine phosphodiesterase activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Predicted to act upstream of or within several processes, including cellular response to pH; regulation of melanocyte differentiation; and skeletal system development. Part of heterotrimeric G-protein complex. Is active in presynapse. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 136.4), Kidney (RPKM 135.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gna11 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8814285..8828628)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8163520..8177863)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11033400..11047284)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene G protein subunit alpha 15 Neighboring gene sphingosine-1-phosphate receptor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity  
    enables G protein activity  
    enables G protein-coupled receptor binding  
    enables G protein-coupled receptor binding  
    enables G-protein beta/gamma-subunit complex binding  
    enables G-protein beta/gamma-subunit complex binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables alkylglycerophosphoethanolamine phosphodiesterase activity PubMed 
    enables enzyme regulator activity  
    enables enzyme regulator activity  
    enables guanyl nucleotide binding PubMed 
    enables metal ion binding  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway  
    involved_in action potential  
    involved_in action potential  
    acts_upstream_of_or_within action potential  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in cellular response to pH  
    acts_upstream_of_or_within cellular response to pH  
    involved_in cranial skeletal system development  
    involved_in cranial skeletal system development  
    involved_in developmental pigmentation  
    acts_upstream_of_or_within developmental pigmentation  
    involved_in endothelin receptor signaling pathway  
    involved_in endothelin receptor signaling pathway  
    NOT acts_upstream_of_or_within glutamate receptor signaling pathway  
    involved_in heart development  
    acts_upstream_of_or_within heart development  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
    involved_in ion channel modulating, G protein-coupled receptor signaling pathway  
    involved_in ligand-gated ion channel signaling pathway  
    involved_in ligand-gated ion channel signaling pathway  
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway  
    involved_in positive regulation of insulin secretion  
    involved_in positive regulation of insulin secretion  
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure  
    involved_in regulation of melanocyte differentiation  
    acts_upstream_of_or_within regulation of melanocyte differentiation  
    involved_in skeletal system development  
    acts_upstream_of_or_within skeletal system development  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of heterotrimeric G-protein complex  
    part_of heterotrimeric G-protein complex PubMed 
    part_of heterotrimeric G-protein complex  
    is_active_in plasma membrane  
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    guanine nucleotide-binding protein subunit alpha-11
    Names
    g alpha-11
    guanine nucleotide binding protein, alpha 11
    guanine nucleotide regulatory protein G alpha 11
    guanine nucleotide-binding protein alpha 11 subunit
    heterotrimeric guanine nucleotide-binding protein 1k

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031033.2NP_112295.2  guanine nucleotide-binding protein subunit alpha-11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9JID2
      UniProtKB/TrEMBL
      A6K871, G3V6Q6
      Related
      ENSRNOP00000007498.3, ENSRNOT00000007498.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8814285..8828628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.