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    Lsm11 LSM11, U7 small nuclear RNA associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501688, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lsm11provided by RGD
    Official Full Name
    LSM11, U7 small nuclear RNA associatedprovided by RGD
    Primary source
    RGD:1565523
    See related
    EnsemblRapid:ENSRNOG00000005450 AllianceGenome:RGD:1565523
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565523
    Summary
    Predicted to enable U7 snRNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage; positive regulation of G1/S transition of mitotic cell cycle; and regulation of chromatin organization. Predicted to be located in nuclear body. Predicted to be part of U7 snRNP; histone pre-mRNA 3'end processing complex; and telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human LSM11 (LSM11, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 82.2), Heart (RPKM 42.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Lsm11 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30869168..30887275, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30367841..30385956, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (31023561..31041700, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095082 Neighboring gene clathrin interactor 1 Neighboring gene tRNA-histidine guanylyltransferase 1-like Neighboring gene SRY-box transcription factor 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of U7 snRNP  
    part_of histone pre-mRNA 3'end processing complex  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    part_of telomerase holoenzyme complex  

    General protein information

    Preferred Names
    U7 snRNA-associated Sm-like protein LSm11
    Names
    U7 snRNP-specific Sm-like protein LSM11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173384.1NP_001166855.1  U7 snRNA-associated Sm-like protein LSm11

      See identical proteins and their annotated locations for NP_001166855.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158836
      UniProtKB/TrEMBL
      A6HDQ3, B0BNI4, F7FQ27
      Related
      ENSRNOP00000007267.4, ENSRNOT00000007267.8
      Conserved Domains (1) summary
      cd01739
      Location:160225
      LSm11_M; Like-Sm protein 11, middle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      30869168..30887275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246151.5XP_006246213.1  U7 snRNA-associated Sm-like protein LSm11 isoform X1

      Related
      ENSRNOP00000111519.1, ENSRNOT00000147861.1
      Conserved Domains (1) summary
      cl00259
      Location:160198
      Sm_like; Sm and related proteins
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