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    Ergic2 ERGIC and golgi 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297728, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ergic2provided by RGD
    Official Full Name
    ERGIC and golgi 2provided by RGD
    Primary source
    RGD:1310606
    See related
    EnsemblRapid:ENSRNOG00000001852 AllianceGenome:RGD:1310606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310606
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and nucleolus. Predicted to be part of retrograde transporter complex, Golgi to ER. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 325.1), Heart (RPKM 248.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ergic2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (182822225..182858392, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181090808..181123074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (182569086..182600258, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486874 Neighboring gene uncharacterized LOC108350795 Neighboring gene fatty acyl CoA reductase 2 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene ribosomal protein S4, X-linked, pseudogene 13 Neighboring gene thymosin beta-10-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in cytoplasm  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum-Golgi intermediate compartment  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in intracellular membrane-bounded organelle  
    is_active_in membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  
    part_of retrograde transporter complex, Golgi to ER  
    part_of transporter complex  

    General protein information

    Preferred Names
    endoplasmic reticulum-Golgi intermediate compartment protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394930.1NP_001381859.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52
      Related
      ENSRNOP00000070726.1, ENSRNOT00000079291.3
      Conserved Domains (2) summary
      pfam07970
      Location:170332
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:1395
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)
    2. NM_001394931.1NP_001381860.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RNA

    1. NR_172212.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      182822225..182858392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285924.1XP_063141994.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52
    2. XM_063285922.1XP_063141992.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52
    3. XM_063285925.1XP_063141995.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

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