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    Gvin2 GTPase, very large interferon inducible, family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 100042856, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gvin2provided by MGI
    Official Full Name
    GTPase, very large interferon inducible, family member 2provided by MGI
    Primary source
    MGI:MGI:3782245
    See related
    Ensembl:ENSMUSG00000078606 AllianceGenome:MGI:3782245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4070; VLIG-1
    Summary
    Orthologous to human GVINP1 (GTPase, very large interferon inducible pseudogene 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 1.7), mammary gland adult (RPKM 1.5) and 21 other tissues See more
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    Genomic context

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    See Gvin2 in Genome Data Viewer
    Location:
    7 E3; 7 55.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105544325..105603174, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105895118..105953967, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible, pseudogene 1 Neighboring gene predicted gene 15645 Neighboring gene GTPase, very large interferon inducible, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113101005-113101306 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113102439-113102740 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113198665-113198966 Neighboring gene GTPase, very large interferon inducible, pseudogene 3 Neighboring gene ornithine decarboxylase, structural 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry. Dai J, et al. J Proteome Res, 2007 Jan. PMID 17203969
    2. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. Klamp T, et al. J Immunol, 2003 Aug 1. PMID 12874213
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced very large GTPase 1
    Names
    very large inducible GTPase-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243039.1 → NP_001229968.1  interferon-induced very large GTPase 1

      See identical proteins and their annotated locations for NP_001229968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY167972, BY199517, BY577205, BY579139
      Consensus CDS
      CCDS57577.1
      UniProtKB/Swiss-Prot
      Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
      Related
      ENSMUSP00000135898.2, ENSMUST00000176467.8
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001243040.1 → NP_001229969.1  interferon-induced very large GTPase 1

      See identical proteins and their annotated locations for NP_001229969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two internal exons in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AY167972, AY167973, BY199517, BY577205, BY579139
      Consensus CDS
      CCDS57577.1
      UniProtKB/Swiss-Prot
      Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
      Related
      ENSMUSP00000102377.3, ENSMUST00000106766.9
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105544325..105603174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321896.1 → XP_017177385.1  interferon-induced very large GTPase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80SU7.1 GenPept UniProtKB/Swiss-Prot:Q80SU7

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