Sult1e1 sulfotransferase family 1E member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sult1e1provided by RGD
Full Name: sulfotransferase family 1E member 1provided by RGD
Primary source: RGD:3776
See related: EnsemblRapid:ENSRNOG00000001957 AllianceGenome:RGD:3776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ste; Ste1; ste2; EST-1; EST-2; EST-3; EST-6; ST1E1; ESTSUL; rEST-6
Summary: Enables estrone sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; estrogen catabolic process; and ethanol catabolic process. Predicted to act upstream of or within female pregnancy and sulfation. Predicted to be located in cytosol and nuclear membrane. Human ortholog(s) of this gene implicated in breast cancer and endometrial cancer. Orthologous to human SULT1E1 (sulfotransferase family 1E member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 2325.7) See more
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Genomic context

Location:: 14p21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (20700444..20718719)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (20422324..20439562)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (22070861..22089264)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression of SULT2B1a, which catalyzes pregnenolone sulfate production, is inhibited by activation of excitatory amino acid receptors of the AMPA subtype, via facilitation of intracellular NO signaling.
Title: Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

D14Wox19 (e-PCR)
- UniSTS:518920

D14Arb6 (e-PCR), detects polymorphism
- UniSTS:226600

D14Wox31 (e-PCR)
- UniSTS:518589

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables estrone sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables flavonol 3-sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables flavonol 3-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables steroid sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables steroid sulfotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables sulfotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in ethanol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ethanol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sulfation	ISO Inferred from Sequence Orthology more info
involved_in sulfation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sulfotransferase 1E1

Names: estrogen sulfotransferase; estrone sulfotransferase; sulfotransferase family 1E, estrogen-preferring, member 1; sulfotransferase, estrogen-preferring

NP_037015.2

EC 2.8.2.4

XP_063129379.1

EC 2.8.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012883.2 → NP_037015.2 sulfotransferase 1E1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P49889, P49890, P52844, P52845, Q9QWS0

UniProtKB/TrEMBL

F7FNI2, Q99ND5

Conserved Domains (1) summary

pfam00685
Location:38 → 288

Sulfotransfer_1; Sulfotransferase domain