Anln anillin, actin binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Anlnprovided by RGD
Official Full Name: anillin, actin binding proteinprovided by RGD
Primary source: RGD:1561367
See related: EnsemblRapid:ENSRNOG00000014343 AllianceGenome:RGD:1561367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561367
Summary: Predicted to enable actin binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; podocyte cell migration; and positive regulation of bleb assembly. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 101.6), Spleen (RPKM 76.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (29134222..29197513, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (20858227..20921602, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (23336455..23397122, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE112541 (e-PCR)
- UniSTS:246113

AI411572 (e-PCR)
- UniSTS:250565

RH128360 (e-PCR)
- UniSTS:211668

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in actomyosin contractile ring	ISO Inferred from Sequence Orthology more info
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anillin

Names: actin-binding protein anillin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427480.1 → NP_001414409.1 anillin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AE50, A0A8I6AE68

Related

ENSRNOP00000092584.1, ENSRNOT00000098083.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

29134222..29197513 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082267.2 → XP_038938195.1 anillin isoform X1

UniProtKB/TrEMBL

A0A8I6AE50

Related

ENSRNOP00000092675.2, ENSRNOT00000109771.2

Conserved Domains (4) summary

PHA03307
Location:26 → 200

PHA03307; transcriptional regulator ICP4; Provisional

cd01263
Location:993 → 1120

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam08174
Location:792 → 945

Anillin; Cell division protein anillin

pfam16018
Location:135 → 221

Anillin_N; Anillin N-terminus