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    Psme1 proteasome activator subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29630, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psme1provided by RGD
    Official Full Name
    proteasome activator subunit 1provided by RGD
    Primary source
    RGD:3429
    See related
    EnsemblRapid:ENSRNOG00000019041 AllianceGenome:RGD:3429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase activator activity. Predicted to be involved in positive regulation of endopeptidase activity; regulation of G1/S transition of mitotic cell cycle; and regulation of proteasomal protein catabolic process. Predicted to act upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human PSME1 (proteasome activator subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1850.7), Spleen (RPKM 1041.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psme1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33038962..33041849)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29069012..29071888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34256071..34258947)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552219 Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome activator subunit 2 Neighboring gene ring finger protein 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleoplasm  
    part_of proteasome activator complex  

    General protein information

    Preferred Names
    proteasome activator complex subunit 1
    Names
    11S regulator complex subunit alpha
    PA28a
    PA28alpha
    REG-alpha
    activator of multicatalytic protease subunit 1
    protease (prosome, macropain) 28 subunit, alpha
    proteasome (prosome, macropain) 28 subunit, alpha
    proteasome (prosome, macropain) activator subunit 1
    proteasome activator 28 subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017264.3NP_058960.2  proteasome activator complex subunit 1

      See identical proteins and their annotated locations for NP_058960.2

      Status: PROVISIONAL

      Source sequence(s)
      BC060574
      UniProtKB/Swiss-Prot
      Q63797
      UniProtKB/TrEMBL
      F7F0J8, Q6P9V7
      Related
      ENSRNOP00000096823.1, ENSRNOT00000111999.2
      Conserved Domains (2) summary
      pfam02251
      Location:868
      PA28_alpha; Proteasome activator pa28 alpha subunit
      pfam02252
      Location:104246
      PA28_beta; Proteasome activator pa28 beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33038962..33041849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274189.1XP_063130259.1  proteasome activator complex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      Q63797
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