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    Prph peripherin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24688, updated on 27-Dec-2024

    Summary

    Official Symbol
    Prphprovided by RGD
    Official Full Name
    peripherinprovided by RGD
    Primary source
    RGD:3414
    See related
    EnsemblRapid:ENSRNOG00000052880 AllianceGenome:RGD:3414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Perf; Prph1
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in intermediate filament cytoskeleton organization. Located in neuronal cell body; terminal bouton; and type III intermediate filament. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 1. Orthologous to human PRPH (peripherin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 34.2), Brain (RPKM 24.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prph in Genome Data Viewer
    Location:
    7q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132096888..132101070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130218149..130222136)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140742406..140746197)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene uncharacterized LOC120093830 Neighboring gene uncharacterized LOC102546594 Neighboring gene trophinin associated protein Neighboring gene complement C1q like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables structural constituent of cytoskeleton  
    enables structural molecule activity  
    Component Evidence Code Pubs
    located_in C-fiber  
    is_active_in axon  
    located_in axon  
    is_active_in cytoplasm  
    located_in intermediate filament  
    located_in intermediate filament  
    located_in neurofilament  
    located_in neuronal cell body PubMed 
    located_in perikaryon  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment membrane  
    is_active_in plasma membrane  
    located_in terminal bouton PubMed 
    located_in terminal bouton  
    is_active_in type III intermediate filament  
    located_in type III intermediate filament PubMed 

    General protein information

    Preferred Names
    peripherin
    Names
    peripherin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012633.3NP_036765.3  peripherin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P21807
      UniProtKB/TrEMBL
      A6KCD5
      Related
      ENSRNOP00000072008.2, ENSRNOT00000089211.3
      Conserved Domains (2) summary
      pfam00038
      Location:99409
      Filament; Intermediate filament protein
      pfam04732
      Location:2198
      Filament_head; Intermediate filament head (DNA binding) region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132096888..132101070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765669.4XP_008763891.1  peripherin isoform X2

      UniProtKB/TrEMBL
      A0A8I6AT59, Q496Z5
      Conserved Domains (2) summary
      pfam00038
      Location:99441
      Filament; Intermediate filament protein
      pfam04732
      Location:2198
      Filament_head; Intermediate filament head (DNA binding) region
    2. XM_006257321.5XP_006257383.1  peripherin isoform X1

      See identical proteins and their annotated locations for XP_006257383.1

      UniProtKB/Swiss-Prot
      P21807
      UniProtKB/TrEMBL
      A6KCD4
      Related
      ENSRNOP00000097710.2, ENSRNOT00000094354.2
      Conserved Domains (2) summary
      pfam00038
      Location:99441
      Filament; Intermediate filament protein
      pfam04732
      Location:2198
      Filament_head; Intermediate filament head (DNA binding) region
    3. XM_063262998.1XP_063119068.1  peripherin isoform X3

      UniProtKB/TrEMBL
      F1M7P4, Q496Z5
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