Slc35a4 solute carrier family 35, member A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc35a4provided by RGD
Official Full Name: solute carrier family 35, member A4provided by RGD
Primary source: RGD:628792
See related: EnsemblRapid:ENSRNOG00000002908 AllianceGenome:RGD:628792
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plrr4; Plrr-4
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in positive regulation of cellular respiration; positive regulation of translation in response to stress; and transmembrane transport. Located in Golgi apparatus. Orthologous to human SLC35A4 (solute carrier family 35 member A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 183.6), Thymus (RPKM 168.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (28555471..28558639)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (28280483..28284610)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (29505239..29509304)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

complex leucine repeat protein (Clrp, Plrr4) of the Golgi apparatus expressed by specific neurons of the rat brain.
Title: Cloning of the cDNA and mRNA expression of CLRP, a complex leucine repeat protein of the Golgi apparatus expressed by specific neurons of the rat brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pyrimidine nucleotide-sugar transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation in response to stress	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide-sugar transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: probable UDP-sugar transporter protein SLC35A4

Names: PLRR-4 polymorphic leucine-rich repeat protein; complex leucine repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432747.1 → NP_001419676.1 probable UDP-sugar transporter protein SLC35A4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q5RKL6, Q91ZR7

UniProtKB/TrEMBL

A6J325
NM_001432748.1 → NP_001419677.1 probable UDP-sugar transporter protein SLC35A4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q5RKL6, Q91ZR7

UniProtKB/TrEMBL

A6J325
NM_147140.3 → NP_671481.2 probable UDP-sugar transporter protein SLC35A4

See identical proteins and their annotated locations for NP_671481.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q5RKL6, Q91ZR7

UniProtKB/TrEMBL

A6J325

Related

ENSRNOP00000096880.1, ENSRNOT00000100525.2

Conserved Domains (1) summary

pfam04142
Location:83 → 320

Nuc_sug_transp; Nucleotide-sugar transporter