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    Slc2a1 solute carrier family 2 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24778, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc2a1provided by RGD
    Official Full Name
    solute carrier family 2 member 1provided by RGD
    Primary source
    RGD:3704
    See related
    EnsemblRapid:ENSRNOG00000007284 AllianceGenome:RGD:3704
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GTG1; Gtg3; GLUTB; Glut1; RATGTG1
    Summary
    Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 185.1), Kidney (RPKM 121.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Slc2a1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138002522..138030742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (132717196..132745416)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138154677..138182897)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene Neighboring gene uncharacterized LOC108351021 Neighboring gene uncharacterized LOC120102964 Neighboring gene zinc finger protein 691 Neighboring gene erythroblast membrane associated protein (Scianna blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in D-glucose import  
    involved_in D-glucose import PubMed 
    involved_in D-glucose import across plasma membrane  
    involved_in D-glucose transmembrane transport PubMed 
    involved_in D-glucose transmembrane transport  
    involved_in D-glucose transmembrane transport  
    involved_in cellular hyperosmotic response PubMed 
    acts_upstream_of_or_within cellular response to glucose starvation  
    involved_in cellular response to mechanical stimulus PubMed 
    acts_upstream_of_or_within central nervous system development  
    involved_in cerebral cortex development PubMed 
    involved_in dehydroascorbic acid transport  
    involved_in dehydroascorbic acid transport PubMed 
    involved_in dehydroascorbic acid transport  
    involved_in female pregnancy PubMed 
    involved_in long-chain fatty acid import across plasma membrane  
    involved_in photoreceptor cell maintenance  
    involved_in photoreceptor cell maintenance  
    involved_in protein-containing complex assembly  
    involved_in protein-containing complex assembly  
    involved_in response to Thyroglobulin triiodothyronine PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to insulin  
    involved_in response to insulin PubMed 
    acts_upstream_of_or_within transport across blood-brain barrier  
    involved_in transport across blood-brain barrier  
    involved_in xenobiotic transport PubMed 
    Items 1 - 25 of 27
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    is_active_in Golgi membrane  
    located_in Z disc PubMed 
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane PubMed 
    located_in basolateral plasma membrane  
    located_in caveola PubMed 
    located_in cell-cell junction PubMed 
    located_in cortical actin cytoskeleton  
    located_in cortical actin cytoskeleton  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in female germ cell nucleus  
    located_in female pronucleus  
    part_of glucose transporter complex  
    located_in intercalated disc PubMed 
    located_in membrane  
    located_in membrane raft  
    located_in midbody  
    located_in photoreceptor inner segment  
    located_in photoreceptor inner segment  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in presynapse  
    located_in sarcolemma PubMed 
    located_in synapse  
    located_in vesicle  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 1
    Names
    GLUT-1
    Solute carrier family 2 a 1 (facilitated glucose transporter) brain
    glucose transporter type 1, erythrocyte/brain
    solute carrier family 2 (facilitated glucose transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138827.2NP_620182.1  solute carrier family 2, facilitated glucose transporter member 1

      See identical proteins and their annotated locations for NP_620182.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P11167
      UniProtKB/TrEMBL
      A0A8I6ABD3, A6JZL0
      Related
      ENSRNOP00000061340.1, ENSRNOT00000064452.4
      Conserved Domains (1) summary
      cd17431
      Location:14458
      MFS_GLUT_Class1; Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      138002522..138030742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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