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    Spcs3 signal peptidase complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spcs3provided by RGD
    Official Full Name
    signal peptidase complex subunit 3provided by RGD
    Primary source
    RGD:1588184
    See related
    EnsemblRapid:ENSRNOG00000038933 AllianceGenome:RGD:1588184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 618.0), Spleen (RPKM 374.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spcs3 in Genome Data Viewer
    Location:
    16p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (44038421..44043855)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (37305358..37310792)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (40050862..40056296)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 4 Neighboring gene ankyrin repeat and SOCS box-containing 5 Neighboring gene U6 spliceosomal RNA Neighboring gene pancreatic progenitor cell differentiation and proliferation factor-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Chen Q, et al. Mol Cell, 2016 Aug 18. PMID 27499293, Free PMC Article
    2. Membrane topology and biogenesis of eukaryotic signal peptidase. Shelness GS, et al. J Biol Chem, 1993 Mar 5. PMID 8444896
    3. Purification of microsomal signal peptidase as a complex. Evans EA, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3511473, Free PMC Article
    4. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
    5. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies KU, et al. J Biol Chem, 1996 Feb 16. PMID 8632014

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit 3
    Names
    signal peptidase complex subunit 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191073.1 → NP_001178002.1  signal peptidase complex subunit 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZF12
      Related
      ENSRNOP00000062708.2, ENSRNOT00000067375.5
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      44038421..44043855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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