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    Cars1 cysteinyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293638, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cars1provided by RGD
    Official Full Name
    cysteinyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1310747
    See related
    EnsemblRapid:ENSRNOG00000020651 AllianceGenome:RGD:1310747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cars
    Summary
    Predicted to enable several functions, including ATP binding activity; cysteine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 143.9), Brain (RPKM 100.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cars1 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208183092..208225425, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198753689..198796016, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216759367..216801652, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology-like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene small nucleolar RNA, H/ACA box 54 Neighboring gene uncharacterized LOC134483952 Neighboring gene transfer RNA valine (anticodon AAC) 16 Neighboring gene tumor necrosis factor receptor superfamily, member 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables cysteine-tRNA ligase activity  
    enables cysteine-tRNA ligase activity  
    enables identical protein binding  
    enables metal ion binding  
    enables protein homodimerization activity  
    enables tRNA binding  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation  
    involved_in cysteinyl-tRNA aminoacylation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    cysteine--tRNA ligase, cytoplasmic
    Names
    cysteinyl-tRNA synthetase, cytoplasmic
    NP_001099789.1
    XP_006230775.1
    XP_038964041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106319.1NP_001099789.1  cysteine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001099789.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6AVG0, A6HYC5, G3V9K0
      Related
      ENSRNOP00000050342.2, ENSRNOT00000050721.5
      Conserved Domains (2) summary
      cd00672
      Location:30445
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:1745
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208183092..208225425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230713.5XP_006230775.1  cysteine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006230775.1

      UniProtKB/TrEMBL
      A0A8I5Y9V4, A0A8I6AVG0, A6HYC6
      Related
      ENSRNOP00000078006.1, ENSRNOT00000097888.2
      Conserved Domains (3) summary
      cd00672
      Location:113528
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      cd10310
      Location:476
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91828
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    2. XM_039108113.2XP_038964041.1  cysteine--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVG0
      Conserved Domains (1) summary
      PTZ00399
      Location:1681
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
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