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    Cfap410 cilia and flagella associated protein 410 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap410provided by RGD
    Official Full Name
    cilia and flagella associated protein 410provided by RGD
    Primary source
    RGD:1309594
    See related
    EnsemblRapid:ENSRNOG00000001215 AllianceGenome:RGD:1309594
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309594
    Summary
    Predicted to be involved in cytoskeleton organization and regulation of cell shape. Predicted to act upstream of or within cilium assembly and smoothened signaling pathway. Predicted to be located in several cellular components, including ciliary basal body; mitochondrion; and photoreceptor cell cilium. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 59.4), Brain (RPKM 49.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cfap410 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10687506..10694366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10687863..10694736, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11417428..11424301, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene autoimmune regulator Neighboring gene phosphofructokinase, liver type Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene Z6 small nucleolar RNA Neighboring gene Z6 small nucleolar RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy. Suga A, et al. Invest Ophthalmol Vis Sci, 2016 Aug 1. PMID 27548899
    2. Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3. Krohn K, et al. Biochem Biophys Res Commun, 1997 Sep 29. PMID 9325172
    3. Axial Spondylometaphyseal Dysplasia Is Caused by C21orf2 Mutations. Wang Z, et al. PLoS One, 2016. PMID 26974433, Free PMC Article
    4. C21orf2 is mutated in recessive early-onset retinal dystrophy with macular staphyloma and encodes a protein that localises to the photoreceptor primary cilium. Khan AO, et al. Br J Ophthalmol, 2015 Dec. PMID 26294103
    5. The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair. Fang X, et al. Acta Biochim Biophys Sin (Shanghai), 2015 Oct. PMID 26290490, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95110

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor cell cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cilia and flagella associated protein 410

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008351.1 → NP_001008352.1  cilia and flagella associated protein 410

      See identical proteins and their annotated locations for NP_001008352.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085944
      UniProtKB/TrEMBL
      A0A8I6G609, F7FCR2, Q5RKG5
      Related
      ENSRNOP00000045156.3, ENSRNOT00000049745.6
      Conserved Domains (3) summary
      sd00035
      Location:42 → 63
      LRR_NTF; leucine-rich repeat [structural motif]
      NF033189
      Location:1 → 204
      internalin_A; class 1 internalin InlA
      cd21340
      Location:40 → 130
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10687506..10694366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256252.4 → XP_006256314.1  cilia and flagella associated protein 410 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G609
      Conserved Domains (2) summary
      sd00035
      Location:4 → 25
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam12799
      Location:2 → 42
      LRR_4; Leucine Rich repeats (2 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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