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    Kat2b lysine acetyltransferase 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301164, updated on 9-Dec-2024

    Summary

    Symbol
    Kat2bprovided by RGD
    Full Name
    lysine acetyltransferase 2Bprovided by RGD
    Primary source
    RGD:1305902
    See related
    EnsemblRapid:ENSRNOG00000011871 AllianceGenome:RGD:1305902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcaf; AABR07066180.1
    Summary
    Enables chromatin binding activity; histone acetyltransferase binding activity; and histone deacetylase binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; memory; and positive regulation of transcription by RNA polymerase II. Located in chromatin. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 351.2), Heart (RPKM 315.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Kat2b in Genome Data Viewer
    Location:
    9q11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (6799101..6903616)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6562525..6667064)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4440982..4492949, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 49 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene RIKEN cDNA 4932415M13 gene like Neighboring gene shugoshin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables acetyltransferase activity  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity  
    enables histone H3 acetyltransferase activity  
    enables histone H3K9 acetyltransferase activity  
    enables histone acetyltransferase activity  
    enables histone acetyltransferase binding PubMed 
    enables histone deacetylase binding PubMed 
    enables histone deacetylase binding  
    enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor  
    enables peptide-lysine-N-acetyltransferase activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-lysine acetylation  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to parathyroid hormone stimulus PubMed 
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    acts_upstream_of gluconeogenesis  
    acts_upstream_of_or_within internal peptidyl-lysine acetylation  
    involved_in internal peptidyl-lysine acetylation  
    involved_in memory PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of centriole replication  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of rRNA processing  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in peptidyl-lysine acetylation  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore  
    involved_in positive regulation of fatty acid biosynthetic process  
    acts_upstream_of_or_within positive regulation of gluconeogenesis  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of lipid biosynthetic process  
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription from RNA polymerase II promoter by glucose  
    involved_in protein acetylation PubMed 
    involved_in protein acetylation  
    involved_in vasodilation PubMed 
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in A band  
    part_of ATAC complex  
    part_of ATAC complex  
    located_in I band  
    located_in actomyosin  
    located_in centrosome  
    located_in chromatin PubMed 
    located_in cytosol  
    located_in cytosol  
    part_of histone acetyltransferase complex  
    located_in kinetochore  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    histone acetyltransferase KAT2B
    Names
    K(lysine) acetyltransferase 2B
    p300/CBP-associated factor
    NP_001019423.2
    XP_038940325.1
    XP_038940326.1
    XP_038940327.1
    XP_038940328.1
    XP_063122903.1
    XP_063122904.1
    XP_063122905.1
    XP_063122906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024252.2NP_001019423.2  histone acetyltransferase KAT2B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5Y222, A6KUI5
      Related
      ENSRNOP00000078189.1, ENSRNOT00000104333.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      6799101..6903616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084397.2XP_038940325.1  histone acetyltransferase KAT2B isoform X2

      UniProtKB/TrEMBL
      A0A8J8YC15, A6KUI5
      Conserved Domains (3) summary
      cd05509
      Location:660759
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:468759
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:56307
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    2. XM_063266836.1XP_063122906.1  histone acetyltransferase KAT2B isoform X7

    3. XM_063266833.1XP_063122903.1  histone acetyltransferase KAT2B isoform X1

      UniProtKB/TrEMBL
      A6KUI5
      Related
      ENSRNOP00000110742.1, ENSRNOT00000128479.1
    4. XM_063266835.1XP_063122905.1  histone acetyltransferase KAT2B isoform X5

      UniProtKB/TrEMBL
      A6KUI5
    5. XM_063266834.1XP_063122904.1  histone acetyltransferase KAT2B isoform X4

      UniProtKB/TrEMBL
      A6KUI5
    6. XM_039084398.2XP_038940326.1  histone acetyltransferase KAT2B isoform X3

      UniProtKB/TrEMBL
      A6KUI5
      Related
      ENSRNOP00000058599.6, ENSRNOT00000061882.6
      Conserved Domains (3) summary
      cd05509
      Location:633732
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:393732
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:11232
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    7. XM_039084399.2XP_038940327.1  histone acetyltransferase KAT2B isoform X6

      UniProtKB/TrEMBL
      A6KUI5
      Conserved Domains (3) summary
      cd05509
      Location:569668
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:329668
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam06466
      Location:1168
      PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    8. XM_039084400.2XP_038940328.1  histone acetyltransferase KAT2B isoform X8

      Conserved Domains (2) summary
      cd05509
      Location:381480
      Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
      COG5076
      Location:141480
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
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