Traip TRAF-interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Traipprovided by RGD
Official Full Name: TRAF-interacting proteinprovided by RGD
Primary source: RGD:1309761
See related: EnsemblRapid:ENSRNOG00000030101 AllianceGenome:RGD:1309761
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of interferon-beta production; negative regulation of tumor necrosis factor-mediated signaling pathway; and replication fork processing. Predicted to act upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 31.1), Spleen (RPKM 16.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117520476..117540253)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108641860..108661640)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116730170..116750528)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

PMC126259P2 (e-PCR)
- UniSTS:270537

RH137038 (e-PCR)
- UniSTS:219127

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of DNA damage	IBA Inferred from Biological aspect of Ancestor more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRAIP

NP_001102474.1

EC 2.3.2.27

XP_038937815.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109004.2 → NP_001102474.1 E3 ubiquitin-protein ligase TRAIP

See identical proteins and their annotated locations for NP_001102474.1

Status: PROVISIONAL

Source sequence(s)

BC162006

UniProtKB/TrEMBL

A0A8I6GLQ9, B1WC52, F7ETT8

Related

ENSRNOP00000048198.3, ENSRNOT00000052289.6

Conserved Domains (2) summary

pfam13639
Location:7 → 50

zf-RING_2; Ring finger domain

cl12013
Location:106 → 264

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

117520476..117540253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081887.2 → XP_038937815.1 E3 ubiquitin-protein ligase TRAIP isoform X1

Conserved Domains (1) summary

COG1196
Location:4 → 137

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]