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    Mars2 methionyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911305, updated on 9-Dec-2024

    Summary

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    Symbol
    Mars2provided by RGD
    Full Name
    methionyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1311527
    See related
    EnsemblRapid:ENSRNOG00000065339 AllianceGenome:RGD:1311527
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311527
    Summary
    Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Mars2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (64214935..64228408)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56720408..56729991)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61823441..61826357)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2 Neighboring gene boule homolog, RNA binding protein Neighboring gene uncharacterized LOC120094794 Neighboring gene uncharacterized LOC134480577 Neighboring gene phospholipase C-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human mitochondrial methionyl-tRNA synthetase. Spencer AC, et al. Biochemistry, 2004 Aug 3. PMID 15274629
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine--tRNA ligase, mitochondrial
    Names
    methionine--tRNA ligase, mitochondrial-like
    methionine-tRNA synthetase 2 (mitochondrial)
    methionyl-tRNA synthetase, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      64214935..64228408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084841.2 → XP_038940769.1  methionine--tRNA ligase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00015
      Location:37 → 301
      nt_trans; nucleotidyl transferase superfamily

    2. XM_039084842.2 → XP_038940770.1  methionine--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cl00015
      Location:37 → 301
      nt_trans; nucleotidyl transferase superfamily

    3. XM_003750699.6 → XP_003750747.1  methionine--tRNA ligase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_003750747.1

      UniProtKB/TrEMBL
      A6IP18, D4A9V7
      Related
      ENSRNOP00000088692.1, ENSRNOT00000114346.2
      Conserved Domains (3) summary
      cd07957
      Location:388 → 532
      Anticodon_Ia_Met; Anticodon-binding domain of methionyl tRNA synthetases
      cd00814
      Location:37 → 379
      MetRS_core; catalytic core domain of methioninyl-tRNA synthetases
      PRK11893
      Location:39 → 574
      PRK11893; methionyl-tRNA synthetase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version

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